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Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
THE stress-activated protein kinases (SAPKs), which are distantly related to the MAP kinases, are the dominant c-Jun amino-termi-nal protein kinases activated in response to a variety of cellularExpand
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Nck and Phosphatidylinositol 4,5-Bisphosphate Synergistically Activate Actin Polymerization through the N-WASP-Arp2/3 Pathway*
The Wiskott-Aldrich syndrome protein (WASP) and its relative neural WASP (N-WASP) regulate the nucleation of actin filaments through their interaction with the Arp2/3 complex and are regulated inExpand
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Catalytic specificity of protein-tyrosine kinases is critical for selective signalling
HOW do distinct protein-tyrosine kinases activate specific downstream events? Src-homology-2 (SH2) domains on tyrosine kinases or targets of tyrosine kinases recognize phosphotyrosine in a specificExpand
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Structure of PAK1 in an Autoinhibited Conformation Reveals a Multistage Activation Switch
The p21-activated kinases (PAKs), stimulated by binding with GTP-liganded forms of Cdc42 or Rac, modulate cytoskeletal actin assembly and activate MAP-kinase pathways. The 2.3 A resolution crystalExpand
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SH3 domains: complexity in moderation.
  • B. Mayer
  • Medicine, Biology
  • Journal of cell science
  • 1 April 2001
The SH3 domain is perhaps the best-characterized member of the growing family of protein-interaction modules. By binding with moderate affinity and selectivity to proline-rich ligands, these domainsExpand
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The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity
Cyclin-dependent kinase 5 (Cdk5) and its neuron-specific regulator p35 (refs 1–4) are essential for neuronal migration and for the laminar configuration of the cerebral cortex. In addition, p35/Cdk5Expand
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Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1.
Pak1, a serine/threonine kinase that regulates the actin cytoskeleton, is an effector of the Rho family GTPases Cdc42 and Rac1. The crystal structure of Pak1 revealed an autoinhibited dimer that mustExpand
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Identification of a ten-amino acid proline-rich SH3 binding site.
The Src homology 3 (SH3) region is a small protein domain present in a very large group of proteins, including cytoskeletal elements and signaling proteins. It is believed that SH3 domains serve asExpand
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Requirement for C3G‐dependent Rap1 activation for cell adhesion and embryogenesis
C3G is a guanine nucleotide exchange factor (GEF) for Rap1, and is activated via Crk adaptor protein. To understand the physiological role of C3G, we generated C3G knockout mice. C3G−/− homozygousExpand
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The pathogen protein EspFU hijacks actin polymerization using mimicry and multivalency
Enterohaemorrhagic Escherichia coli attaches to the intestine through actin pedestals that are formed when the bacterium injects its protein EspFU (also known as TccP) into host cells. EspFU potentlyExpand
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