protein O-GlcNAcylation via threonine

The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine… (More)
National Institutes of Health

Papers overview

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2018
2018
O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1
Cancer cells often heavily depend on the ubiquitin-proteasome system (UPS) for their growth and survival. Irrespective of their… (More)
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2017
2017
Nutrient-driven O-GlcNAc cycling impacts neurodevelopmental timing and metabolism
Nutrient-driven O-GlcNAcylation is strikingly abundant in the brain and has been linked to development and neurodegenerative… (More)
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2016
2016
Proteolysis of HCF-1 by Ser/Thr glycosylation-incompetent O-GlcNAc transferase:UDP-GlcNAc complexes.
In complex with the cosubstrate UDP-N-acetylglucosamine (UDP-GlcNAc),O-linked-GlcNAc transferase (OGT) catalyzes Ser/ThrO… (More)
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2015
2015
O-GlcNAcylation of MLL5β is essential for MLL5β-AP-1 transcription complex assembly at the HPV16/18-long control region.
Dear Editor, Cervical cancer is one of the leading causes of cancer death in women (Munoz et al., 2004), and current treatment… (More)
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Review
2014
Review
2014
Nutrient regulation of signaling, transcription, and cell physiology by O-GlcNAcylation.
The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosolic proteins to regulate many… (More)
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Highly Cited
2013
Highly Cited
2013
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains
The tumour necrosis factor (TNF) family is crucial for immune homeostasis, cell death and inflammation. These cytokines are… (More)
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Highly Cited
2013
Highly Cited
2013
O-GlcNAcylation: A New Cancer Hallmark?
O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a reversible post-translational modification consisting in the addition… (More)
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Highly Cited
2012
Highly Cited
2012
Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids.
Staphylococcus aureus peptidoglycan (PG) is densely functionalized with anionic polymers called wall teichoic acids (WTAs). These… (More)
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2011
2011
A Neutral Diphosphate Mimic Crosslinks the Active Site of Human O-GlcNAc Transferase
Glycosyltransferases (Gtfs) catalyze the formation of a diverse array of glycoconjugates. Small-molecule inhibitors to manipulate… (More)
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Highly Cited
2009
Highly Cited
2009
Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease.
It has been established for a long time that brain glucose metabolism is impaired in Alzheimer's disease. Recent studies have… (More)
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