Skip to search formSkip to main contentSkip to account menu
You are currently offline. Some features of the site may not work correctly.

propiolaldehyde

Known as: 2-propynal 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Aldehydes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
N-Propargylamine protects SH-SY5Y cells from apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, through stabilization of mitochondrial membrane and induction of anti-apoptotic Bcl…
Summary.Propargylamine derivatives, rasagiline and (–)deprenyl, are anti-Parkinson agents and protect neurons from cell death as… 
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 6
2001
2001
Cytochrome P450 2E1 metabolically activates propargyl alcohol: propiolaldehyde-induced hepatocyte cytotoxicity.
Pargyline, an antihypertensive agent and monoamine oxidase inhibitor, induces hepatic GSH depletion and hepatotoxicity in vivo in… 
2000
2000
Identification of metabolites of [1,2,3-(13)C]Propargyl alcohol in mouse urine by (13)C NMR and mass spectrometry and comparison to rat.
Species differences in the metabolism of acetylenic compounds commonly used in the formulation of pharmaceuticals and pesticides… 
1986
1986
Role of propiolaldehyde and other metabolites in the pargyline inhibition of rat liver aldehyde dehydrogenase.
The metabolism of pargyline proceeds by way of three separate cytochrome P-450 catalyzed N-dealkylation reactions: N… 
1984
1984
Inhibition of human aldehyde dehydrogenase isozymes by propiolaldehyde.
Propiolaldehyde--a metabolite of pargyline (Shirota et al., 1979) can function as an inhibitor or as a substrate of human… 
1982
1982
Pargyline-induced hepatotoxicity: possible mediation by the reactive metabolite, propiolaldehyde.
Abstract Pargyline (N-methyl-N-propargylbenzylamine) is metabolized by the hepatic cytochrome P-450 enzymes to the reactive… 
1980
1980
Microsomal N-depropargylation of pargyline to propiolaldehyde, an irreversible inhibitor of mitochondrial aldehyde dehydrogenase.
Rat liver microsomes catalyzed the conversion of pargyline (N-methyl-N-propargylbenzylamine) to propiolaldehyde, a potent… 
1979
1979
Propiolaldehyde, a pargyline metabolite that irreversibly inhibits aldehyde dehydrogenase. Isolation from a hepatic microsomal system.
1978
1978
Inhibition of aldehyde dehydrogenase by propiolaldehyde, a possible metabolite of pargyline.
: Pargyline (Eutonyl) inhibited aldehyde dehydrogenase (AlDH) in vivo in rats as adduced by the elevation of ethanol-derived… 
1970
1970
Prebiotic Synthesis of Propiolaldehyde and Nicotinamide
We have identified propiololdehyde as a product of the action of an electric discharge on mixtures of methane and water or… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE