Metabolism and hemoglobin adduct formation of acrylamide in humans.
- T. Fennell, S. Sumner, M. Friedman
- ChemistryToxicological Sciences
- 1 May 2005
It is indicated that humans metabolize AM via glycidamide to a lesser extent than rodents, and dermal uptake was approximately 6.6% of that observed with oral uptake.
Metabolomics Workbench: An international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools
- Manish Sud, E. Fahy, S. Subramaniam
- BiologyNucleic Acids Res.
- 13 October 2015
The Metabolicomics Workbench provides data from the Common Fund's Metabolomics Resource Cores, metabolite standards, and analysis tools to the wider metabolomics community and seeks data depositions from metabolomics researchers across the world.
Kinetics of elimination of urinary metabolites of acrylamide in humans.
- T. Fennell, S. Sumner, R. Snyder, J. Burgess, M. Friedman
- Chemistry, MedicineToxicological Sciences
- 1 October 2006
It is indicated that skin provides a barrier that slows the absorption of AM, and results in limited systemic availability following dermal exposure to AM.
One Step Forward for Reducing False Positive and False Negative Compound Identifications from Mass Spectrometry Metabolomics Data: New Algorithms for Constructing Extracted Ion Chromatograms and…
- Owen D. Myers, S. Sumner, Shuzhao Li, S. Barnes, Xiuxia Du
- Computer ScienceAnalytical Chemistry
- 17 August 2017
New algorithms that carry out the sequential construction of EICs and detection of E IC peaks are developed and evidence that these new algorithms detect significantly fewer false positives is presented.
Acrylamide: a comparison of metabolism and hemoglobin adducts in rodents following dermal, intraperitoneal, oral, or inhalation exposure.
- S. Sumner, C. C. Williams, R. Snyder, W. Krol, B. Asgharian, T. Fennell
- Chemistry, MedicineToxicological Sciences
- 1 October 2003
Significant species differences in the metabolism and internal dose (Hb-adducts) of AM following inhalation exposure are demonstrated and marked differences in uptake comparing dermal with po and ip administration are demonstrated.
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice
- A. Livanos, T. Greiner, M. Blaser
- Biology, MedicineNature Microbiology
- 22 August 2016
Findings show that early-life antibiotic treatments alter the gut microbiota and its metabolic capacities, intestinal gene expression and T-cell populations, accelerating T1D onset in non-obese diabetic mice.
Pharmacokinetics of dibutylphthalate in pregnant rats.
- T. Fennell, W. Krol, S. Sumner, R. Snyder
- Medicine, BiologyToxicological Sciences
- 1 December 2004
MBP, thought to be the active metabolite of DBP, can cross the placenta in late gestation, and that the metabolism of MBP is saturable is indicated.
Metabolomics enables precision medicine: “A White Paper, Community Perspective”
- R. Beger, W. Dunn, R. Kaddurah-Daouk
- Biology, MedicineMetabolomics
- 2 September 2016
The narrow range of chemical analyses in current use by the medical community today will be replaced in the future by analyses that reveal a far more comprehensive metabolic signature, expected to describe global biochemical aberrations that reflect patterns of variance in states of wellness, more accurately describe specific diseases and their progression, and greatly aid in differential diagnosis.
Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity
- Xue-Song Zhang, Jackie Li, M. Blaser
- Biology, MedicineeLife
- 24 July 2018
This simplified animal model reveals multiple potential pathways to understand pathogenesis by which early-life gut microbiome perturbations alter a global suite of intestinal responses, contributing to the accelerated and enhanced T1D development.
The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes
- Anjelique F. Schulfer, Jonas Schluter, M. Blaser
- BiologyThe ISME Journal
- 16 January 2019
It is shown that cohousing can partly ameliorate the impact of STAT on the gut microbiota but not prevent increased weight with high-fat diet, which has implications for microbiota therapies aimed to resolve the collateral damage of antibiotics and their load on human obesity.