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proline binding

Interacting selectively and non-covalently with proline. [GOC:pm, GOC:TermGenie, PMID:7730362]
National Institutes of Health

Papers overview

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2017
2017
Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy
Scleroderma has clinical characteristics including skin and other tissue fibrosis, but there is an unmet need for anti-fibrotic… Expand
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2015
2015
IQGAP1 regulates actin cytoskeleton organization in podocytes through interaction with nephrin.
Increasing data has shown that the cytoskeletal reorganization of podocytes is involved in the onset of proteinuria and the… Expand
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2014
2014
Structure-based design of novel human Pin1 inhibitors (III): optimizing affinity beyond the phosphate recognition pocket.
The design of potent Pin1 inhibitors has been challenging because its active site specifically recognizes a phospho-protein… Expand
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2011
2011
Homology model of the Na+/proline transporter PutP of Escherichia coli and its functional implications.
Na(+)/solute symporters are essential membrane integrated proteins that couple the flow of Na(+) ions driven by electrochemical… Expand
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2010
2010
Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase
BackgroundThe unique S28 family of proteases is comprised of the carboxypeptidase PRCP and the aminopeptidase DPP7. The… Expand
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2003
2003
Identification of regions of the tomato gamma-glutamyl kinase that are involved in allosteric regulation by proline.
The first step of proline biosynthesis is catalyzed by gamma-glutamyl kinase (GK). To better understand the feedback inhibition… Expand
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2001
2001
A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase.
We describe the recognition by Thermus thermophilus prolyl-tRNA synthetase (ProRSTT) of proline, ATP and prolyl-adenylate and the… Expand
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2001
2001
Methanococcus jannaschii prolyl-cysteinyl-tRNA synthetase possesses overlapping amino acid binding sites.
The protein translation apparatus of Methanococcus jannaschii possesses the unusual enzyme prolyl-cysteinyl-tRNA synthetase… Expand
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1998
1998
A conserved aspartate residue, Asp187, is important for Na+-dependent proline binding and transport by the Na+/proline transporter of Escherichia coli.
Asp187 in the Na+/proline transporter of Escherichia coli (PutP) is conserved within the Na+/solute cotransporter family… Expand
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1992
1992
Sodium ion and proline binding sites in the Na+/proline symport carrier of Escherichia coli.
Proline binding activity of the Escherichia coli Na+/proline symport carrier is inhibited by a sulfhydryl reagent, N… Expand
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