Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

pretubulysin

 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Pretubulysin (PT), a potent tubulin‐binding antitumoral drug, and the well‐established antimetabolite methotrexate (MTX) were… Expand
2017
2017
The conjugation of small molecule drugs to ligand containing carrier systems facilitates receptor targeted delivery. The folate… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
2015
2015
The Ugi reaction is found to be a very powerful tool for the synthesis of (pre)tubulysin derivatives, allowing the introduction… Expand
  • figure 1
  • table 1
  • figure 2
  • table 2
2014
2014
Tubulin-binding agents such as taxol, vincristine or vinblastine are well-established drugs in clinical treatment of metastatic… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 6
2014
2014
Tubulin binding agents are a potent group of cancer chemotherapeutics. Most of these substances are naturally derived compounds… Expand
2014
2014
Objective—Pretubulysin (PT) is a novel, synthetically accessible myxobacterial compound that acts as a tubulin-depolymerizing… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
2012
2012
Microtubules (mt) are highly dynamic polymers composed of alpha- and beta-tubulin monomers that are present in all dividing and… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
2012
2012
BACKGROUND AND PURPOSE The use of tubulin‐binding compounds, which act in part by inhibiting tumour angiogenesis, has become an… Expand
2012
2012
Pretubulysin is a natural product that is found in strains of myxobacteria in only minute amounts. It represents the first enzyme… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2009
Highly Cited
2009
Simplify, simplify, simplify! Pretubulysin (structure without the green substituents), a simplified tubulysin was prepared in the… Expand