pretubulysin

 
National Institutes of Health

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2017
2017
The conjugation of small molecule drugs to ligand containing carrier systems facilitates receptor targeted delivery. The folate… (More)
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2015
2015
The Ugi reaction is found to be a very powerful tool for the synthesis of (pre)tubulysin derivatives, allowing the introduction… (More)
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2014
2014
Tubulin-binding agents such as taxol, vincristine or vinblastine are well-established drugs in clinical treatment of metastatic… (More)
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2014
2014
Tubulin binding agents are a potent group of cancer chemotherapeutics. Most of these substances are naturally derived compounds… (More)
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2012
2012
BACKGROUND AND PURPOSE The use of tubulin-binding compounds, which act in part by inhibiting tumour angiogenesis, has become an… (More)
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2012
2012
The [3+2]-cycloaddition of an azido tripeptide, corresponding to the left hand side of pretubulysin, with a range of alkynes… (More)
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2012
2012
Pretubulysin is a natural product that is found in strains of myxobacteria in only minute amounts. It represents the first enzyme… (More)
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2012
2012
Microtubules (mt) are highly dynamic polymers composed of alpha- and beta-tubulin monomers that are present in all dividing and… (More)
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2009
2009
Simplify, simplify, simplify! Pretubulysin (structure without the green substituents), a simplified tubulysin was prepared in the… (More)
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2009
2009
Pretubulysin, a biosynthetic precursor of the tubulysins, shows potent biological activity in the subnanomolar range towards… (More)
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