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presqualene pyrophosphate

Known as: presqualene diphosphate 
National Institutes of Health

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Related topics

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Broader (1)

Polyisoprenyl Phosphates

Papers overview

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Highly Cited
2015
Highly Cited
2015
Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes
Squalene (SQ) is an intermediate in the biosynthesis of sterols in eukaryotes and a few bacteria and of hopanoids in bacteria… 
Highly Cited
2011
Highly Cited
2011
Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii
Botryococcene biosynthesis is thought to resemble that of squalene, a metabolite essential for sterol metabolism in all… 
Highly Cited
2010
Highly Cited
2010
Targeting isoprenoid biosynthesis for drug discovery: bench to bedside.
  • E. Oldfield
  • Accounts of chemical research
  • 2010
  • Corpus ID: 41729313
The isoprenoid biosynthesis pathways produce the largest class of small molecules in Nature: isoprenoids (also called terpenoids… 
Highly Cited
2010
Highly Cited
2010
Mechanism of action and inhibition of dehydrosqualene synthase
“Head-to-head” terpene synthases catalyze the first committed steps in sterol and carotenoid biosynthesis: the condensation of… 
Review
2007
Review
2007
Endogenous lipid mediators in the resolution of airway inflammation
Acute inflammation in the lung is fundamentally important to host defence, but chronic or excessive inflammation leads to several… 
Review
2004
Review
2004
Botryococcus braunii: a rich source for hydrocarbons and related ether lipids
This paper presents a review on Botryococcus braunii, a cosmopolitan green colonial microalga characterised by a considerable… 
2002
2002
Recombinant squalene synthase. Synthesis of non-head-to-tail isoprenoids in the absence of NADPH.
Squalene synthase (SQase) catalyzes two consecutive reactions in sterol biosynthesis. The first is the condensation of two… 
Highly Cited
2002
Highly Cited
2002
Recombinant squalene synthase. A mechanism for the rearrangement of presqualene diphosphate to squalene.
Squalene synthase (SQase) catalyzes the condensation of two molecules of farnesyl diphosphate (FPP) to form presqualene… 
Highly Cited
1999
Highly Cited
1999
Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a ‘stop’ signaling switch for aspirin‐triggered lipoxin A4
It is of wide interest to understand how opposing extracellular signals (positive or negative) are translated into intracellular… 
Highly Cited
1970
Highly Cited
1970
Studies on the mechanism of squalene biosynthesis. The structure of presqualene pyrophosphate.
Abstract The isolation and characterization of an intermediate between farnesyl pyrophosphate and squalene is described. This… 
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