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presqualene pyrophosphate

Known as: presqualene diphosphate 
National Institutes of Health

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Broader (1)

Polyisoprenyl Phosphates

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Inhibitors of sterol biosynthesis as Staphylococcus aureus antibiotics.
One of the truisms in the medicinal chemistry of antibiotics is that there can never be enough scaffolds and structures, whether… 
Review
2008
Review
2008
Chemical mediators and the resolution of airway inflammation.
Asthma pathobiology is remarkable for chronic airway inflammation that fails to spontaneously resolve. No curative therapy is… 
Highly Cited
2002
Highly Cited
2002
Recombinant squalene synthase. Synthesis of non-head-to-tail isoprenoids in the absence of NADPH.
Squalene synthase (SQase) catalyzes two consecutive reactions in sterol biosynthesis. The first is the condensation of two… 
1995
1995
Inhibition of Mammalian Squalene Synthetase Activity by Zaragozic Acid A Is a Result of Competitive Inhibition Followed by Mechanism-based Irreversible Inactivation
Squalene synthetase (SQS, EC 2.5.1.21) catalyzes the first committed step in the formation of cholesterol and thus represents an… 
Highly Cited
1988
Highly Cited
1988
Purification to homogeneity and some properties of squalene synthetase.
1978
1978
Polyisoprenoid amphiphilic compounds as inhibitors of squalene synthesis and other microsomal enzymes.
1972
1972
The effect of sterol carrier protein on squalene synthesis.
1971
1971
Mechanism of presqualene pyrophosphate-squalene biosynthesis.
Highly Cited
1970
Highly Cited
1970
Studies on the mechanism of squalene biosynthesis. The structure of presqualene pyrophosphate.
Abstract The isolation and characterization of an intermediate between farnesyl pyrophosphate and squalene is described. This… 
1970
1970
Biosynthesis of presqualene pyrophosphate by liver microsomes.
Microsomes from rat liver have been shown to synthesize a squalene precursor from farnesyl pyrophosphate. This intermediate is… 
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