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presqualene pyrophosphate

Known as: presqualene diphosphate 
 
National Institutes of Health

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Related topics

1 relation

Broader (1)

Polyisoprenyl Phosphates

Papers overview

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Highly Cited
2011
Highly Cited
2011
Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii
Botryococcene biosynthesis is thought to resemble that of squalene, a metabolite essential for sterol metabolism in all… Expand
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Highly Cited
2010
Highly Cited
2010
Targeting isoprenoid biosynthesis for drug discovery: bench to bedside.
  • E. Oldfield
  • Accounts of chemical research
  • 2010
    • Corpus ID: 41729313
The isoprenoid biosynthesis pathways produce the largest class of small molecules in Nature: isoprenoids (also called terpenoids… Expand
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2010
2010
Mechanism of action and inhibition of dehydrosqualene synthase
“Head-to-head” terpene synthases catalyze the first committed steps in sterol and carotenoid biosynthesis: the condensation of… Expand
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2006
2006
Identification and Functional Characterization of a Presqualene Diphosphate Phosphatase*
Presqualene diphosphate (PSDP) is a bioactive lipid that rapidly remodels to presqualene monophosphate (PSMP) upon cell… Expand
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2002
2002
Recombinant squalene synthase. Synthesis of non-head-to-tail isoprenoids in the absence of NADPH.
Squalene synthase (SQase) catalyzes two consecutive reactions in sterol biosynthesis. The first is the condensation of two… Expand
2002
2002
Recombinant squalene synthase. A mechanism for the rearrangement of presqualene diphosphate to squalene.
Squalene synthase (SQase) catalyzes the condensation of two molecules of farnesyl diphosphate (FPP) to form presqualene… Expand
Highly Cited
1999
Highly Cited
1999
Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a ‘stop’ signaling switch for aspirin‐triggered lipoxin A4
It is of wide interest to understand how opposing extracellular signals (positive or negative) are translated into intracellular… Expand
Highly Cited
1997
Highly Cited
1997
Polyisoprenyl phosphates in intracellular signalling
In response to environmental stimuli, leukocyte membrane remodelling generates biologically active lipids that can serve as both… Expand
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1987
1987
Squalene synthetase. Solubilization and partial purification of squalene synthetase, copurification of presqualene pyrophosphate and squalene synthetase activities.
Squalene synthetase (farnesyldiphosphate:farnesyldiphosphate farnesyltransferase, EC 2.5.1.21) is an intrinsic microsomal protein… Expand
Highly Cited
1970
Highly Cited
1970
Studies on the mechanism of squalene biosynthesis. The structure of presqualene pyrophosphate.
Abstract The isolation and characterization of an intermediate between farnesyl pyrophosphate and squalene is described. This… Expand
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