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presqualene pyrophosphate

Known as: presqualene diphosphate 
 
National Institutes of Health

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Topic mentions per year

1970-2017
012319702017

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2010
2010
Targeting isoprenoid biosynthesis for drug discovery: bench to bedside.
The isoprenoid biosynthesis pathways produce the largest class of small molecules in Nature: isoprenoids (also called terpenoids… (More)
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2008
2008
Cloning, solubilization, and characterization of squalene synthase from Thermosynechococcus elongatus BP-1.
Squalene synthase (SQS) is a bifunctional enzyme that catalyzes the condensation of two molecules of farnesyl diphosphate (FPP… (More)
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2006
2006
Identification and functional characterization of a presqualene diphosphate phosphatase.
Presqualene diphosphate (PSDP) is a bioactive lipid that rapidly remodels to presqualene monophosphate (PSMP) upon cell… (More)
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2002
2002
Recombinant squalene synthase. Synthesis of non-head-to-tail isoprenoids in the absence of NADPH.
Squalene synthase (SQase) catalyzes two consecutive reactions in sterol biosynthesis. The first is the condensation of two… (More)
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2002
2002
Recombinant squalene synthase. A mechanism for the rearrangement of presqualene diphosphate to squalene.
Squalene synthase (SQase) catalyzes the condensation of two molecules of farnesyl diphosphate (FPP) to form presqualene… (More)
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1999
1999
Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a 'stop' signaling switch for aspirin-triggered lipoxin A4.
It is of wide interest to understand how opposing extracellular signals (positive or negative) are translated into intracellular… (More)
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1998
1998
Function-structure studies and identification of three enzyme domains involved in the catalytic activity in rat hepatic squalene synthase.
Rat hepatic squalene synthase (RSS, EC 2.5.1.21) contains three conserved sections, A, B, and C, that were proposed to be… (More)
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1993
1993
Yeast squalene synthase: expression, purification, and characterization of soluble recombinant enzyme.
Squalene synthase is the first pathway-specific enzyme in the cholesterol biosynthetic pathway. The gene (ERG9) encoding squalene… (More)
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1988
1988
Purification to homogeneity and some properties of squalene synthetase.
Squalene synthetase has been purified to homogeneity from yeast. It is a single polypeptide of Mr 47,000. This enzyme catalyzes… (More)
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1987
1987
Squalene synthetase. Solubilization and partial purification of squalene synthetase, copurification of presqualene pyrophosphate and squalene synthetase activities.
Squalene synthetase (farnesyldiphosphate:farnesyldiphosphate farnesyltransferase, EC 2.5.1.21) is an intrinsic microsomal protein… (More)
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