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presqualene pyrophosphate
Known as:
presqualene diphosphate
National Institutes of Health
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Broader (1)
Polyisoprenyl Phosphates
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes
Jian-Jung Pan
,
J. Solbiati
,
+5 authors
C. Poulter
ACS central science
2015
Corpus ID: 14629414
Squalene (SQ) is an intermediate in the biosynthesis of sterols in eukaryotes and a few bacteria and of hopanoids in bacteria…
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Highly Cited
2011
Highly Cited
2011
Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii
Thomas D. Niehaus
,
S. Okada
,
T. Devarenne
,
D. Watt
,
Vitaliy M. Sviripa
,
J. Chappell
Proceedings of the National Academy of Sciences
2011
Corpus ID: 23497824
Botryococcene biosynthesis is thought to resemble that of squalene, a metabolite essential for sterol metabolism in all…
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Highly Cited
2010
Highly Cited
2010
Targeting isoprenoid biosynthesis for drug discovery: bench to bedside.
E. Oldfield
Accounts of chemical research
2010
Corpus ID: 41729313
The isoprenoid biosynthesis pathways produce the largest class of small molecules in Nature: isoprenoids (also called terpenoids…
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Highly Cited
2010
Highly Cited
2010
Mechanism of action and inhibition of dehydrosqualene synthase
F. Lin
,
Chia-I Liu
,
+7 authors
E. Oldfield
Proceedings of the National Academy of Sciences
2010
Corpus ID: 26422669
“Head-to-head” terpene synthases catalyze the first committed steps in sterol and carotenoid biosynthesis: the condensation of…
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Review
2007
Review
2007
Endogenous lipid mediators in the resolution of airway inflammation
O. Haworth
,
B. Levy
European Respiratory Journal
2007
Corpus ID: 569859
Acute inflammation in the lung is fundamentally important to host defence, but chronic or excessive inflammation leads to several…
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Review
2004
Review
2004
Botryococcus braunii: a rich source for hydrocarbons and related ether lipids
P. Metzger
,
C. Largeau
Applied Microbiology and Biotechnology
2004
Corpus ID: 26975859
This paper presents a review on Botryococcus braunii, a cosmopolitan green colonial microalga characterised by a considerable…
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2002
2002
Recombinant squalene synthase. Synthesis of non-head-to-tail isoprenoids in the absence of NADPH.
M. Jarstfer
,
Donglu Zhang
,
C. Poulter
Journal of the American Chemical Society
2002
Corpus ID: 25985759
Squalene synthase (SQase) catalyzes two consecutive reactions in sterol biosynthesis. The first is the condensation of two…
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Highly Cited
2002
Highly Cited
2002
Recombinant squalene synthase. A mechanism for the rearrangement of presqualene diphosphate to squalene.
B. Blagg
,
M. Jarstfer
,
D. Rogers
,
C. Poulter
Journal of the American Chemical Society
2002
Corpus ID: 955737
Squalene synthase (SQase) catalyzes the condensation of two molecules of farnesyl diphosphate (FPP) to form presqualene…
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Highly Cited
1999
Highly Cited
1999
Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a ‘stop’ signaling switch for aspirin‐triggered lipoxin A4
B. Levy
,
V. Fokin
,
Joanna M. Clark
,
M. Wakelam
,
N. Petasis
,
C. Serhan
FASEB journal : official publication of the…
1999
Corpus ID: 30565894
It is of wide interest to understand how opposing extracellular signals (positive or negative) are translated into intracellular…
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Highly Cited
1970
Highly Cited
1970
Studies on the mechanism of squalene biosynthesis. The structure of presqualene pyrophosphate.
W. Epstein
,
H. Rilling
The Journal of biological chemistry
1970
Corpus ID: 44825101
Abstract The isolation and characterization of an intermediate between farnesyl pyrophosphate and squalene is described. This…
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