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posiphen

National Institutes of Health

Papers overview

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2020
2020
  • Seong-Jin Yu, Kuo-Jen Wu, +6 authors Yun Wang
  • iScience
  • 2020
  • Corpus ID: 211122548
Summary Acetylcholinesterase (AChE) inhibitors have protective and anti-inflammatory actions against brain injury, mediated by… Expand
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2019
2019
Parkinson disease (PD) is a neurodegenerative disease with motor as well as non-motor symptoms, including gastrointestinal… Expand
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2019
2019
Traumatic brain injury (TBI), a major cause of mortality and morbidity, affects 10 million people worldwide, with limited… Expand
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2018
2018
Translational inhibition of amyloid precursor protein (APP) by Posiphen has been shown to reduce APP and its fragments in cell… Expand
2018
2018
Objective: Although cerebral ischemia can activate endogenous reparative processes, such as proliferation of endogenous neural… Expand
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2013
2013
A major pathological hallmark of Alzheimer disease (AD) is the appearance in the brain of senile plaques that are primarily… Expand
Highly Cited
2012
Highly Cited
2012
Aim A first in human study to evaluate tolerability and pharmacokinetics followed by an early proof of mechanism (POM) study to… Expand
2012
2012
There is compelling support for limiting expression of alpha-synuclein (α-syn) in the brains of Parkinson's disease (PD) patients… Expand
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Highly Cited
2010
Highly Cited
2010
Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form… Expand
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Highly Cited
2007
Highly Cited
2007
Major characteristics of Alzheimer's disease (AD) are synaptic loss, cholinergic dysfunction, and abnormal protein depositions in… Expand
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