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phenserine

Known as: (-)-phenserine, (-)-eseroline phenylcarbamate, N-phenylcarbamoyleseroline 
 
National Institutes of Health

Papers overview

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2010
2010
To gather preliminary evidence in Alzheimer's disease (AD) for the efficacy of phenserine, a non-competitive acetylcholinesterase… Expand
Highly Cited
2008
Highly Cited
2008
The effects of (−)‐phenserine (phenserine) and placebo/donepezil treatment on regional cerebral metabolic rate for glucose… Expand
Highly Cited
2007
Highly Cited
2007
Major characteristics of Alzheimer's disease (AD) are synaptic loss, cholinergic dysfunction, and abnormal protein depositions in… Expand
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Highly Cited
2004
Highly Cited
2004
Increased flux through the hexosamine biosynthetic pathway and increased O-linked glycosylation (N-acetylglucosamine [O-GlcNAc… Expand
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Highly Cited
2004
Highly Cited
2004
AbstractPurpose. Stereoselective and sensitive methods employing chiral stationary phase columns for HPLC determination of… Expand
Highly Cited
2001
Highly Cited
2001
The reduction in levels of the potentially toxic amyloid-β peptide (Aβ) has emerged as one of the most important therapeutic… Expand
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Highly Cited
2001
Highly Cited
2001
With the goal of developing potential Alzheimer's pharmacotherapeutics, we have synthesized a series of novel analogues of the… Expand
Highly Cited
1999
Highly Cited
1999
Four novel analogues (8-11) of cymserine (2) were synthesized by methods similar to those recently developed for the total… Expand
Review
1995
Review
1995
I . Historical Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11. Target of… Expand
Highly Cited
1989
Highly Cited
1989
A number of carbamoyl- and N(1)-substituted analogs of physostigmine were synthesized and their in vitro potencies (IC50 values… Expand