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polysialic acid

Known as: POLYSIALIC, polySia 
A highly negative-charged carbohydrate composed of a linear polymer of alpha 2,8-linked sialic acid residue with potential immunotherapeutic activity… 
National Institutes of Health

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Related topics

3 relations
NCIt Antineoplastic Agent Terminologykeyhole limpet hemocyanin/polysialic acid

Broader (1)

Sialic Acids

Papers overview

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Highly Cited
2000
Highly Cited
2000
Biochemical Engineering of Surface α2–8 Polysialic Acid for Immunotargeting Tumor Cells*
To target tumor cells for immunotherapy, we evaluated the feasibility of altering the epitopes on the surface polysialic acid of… 
Highly Cited
2000
Highly Cited
2000
Expression of polysialic acid and STX, a human polysialyltransferase, is correlated with tumor progression in non-small cell lung cancer.
Polysialic acid (PSA) is a carbohydrate composed of a linear homopolymer of alpha-2-8-linked sialic acid residues and is mainly… 
Review
1998
Review
1998
Polysialic acid at the cell surface: Biophysics in service of cell interactions and tissue plasticity
Polysialic acid (PSA) is a long polymer of negatively‐charged sialic acid associated with the neural cell adhesion molecule. PSA… 
Highly Cited
1995
Highly Cited
1995
Enzymatic activity of a developmentally regulated member of the sialyltransferase family (STX): evidence for α2,8‐sialyltransferase activity toward N‐linked oligosaccharides
Highly Cited
1994
Highly Cited
1994
Requirement of polysialic acid for the migration of the O-2A glial progenitor cell from neurohypophyseal explants
While the capacity of O-2A oligodendrocyte progenitors to migrate in cell culture and during in vivo myelin formation is well… 
Highly Cited
1993
Highly Cited
1993
Regulation and activity-dependence of N-cadherin, NCAM isoforms, and polysialic acid on chick myotubes during development
Muscle development in vivo involves a complex sequence of cell-cell interactions in which secondary myotubes first form in… 
Highly Cited
1990
Highly Cited
1990
Neurite outgrowth in response to transfected N-CAM changes during development and is modulated by polysialic acid
Highly Cited
1986
Highly Cited
1986
Altered expression of neuronal cell adhesion molecules induced by nerve injury and repair
Peripheral nerve injury results in short-term and long-term changes in both neurons and glia. In the present study… 
Highly Cited
1986
Highly Cited
1986
Sequence of a cDNA clone encoding the polysialic acid-rich and cytoplasmic domains of the neural cell adhesion molecule N-CAM.
Purified fractions of the neural cell-adhesion molecule N-CAM from embryonic chicken brain contain two similar polypeptides (Mr… 
Highly Cited
1985
Highly Cited
1985
Cleavage of the polysialosyl units of brain glycoproteins by a bacteriophage endosialidase. Involvement of a long oligosaccharide segment in molecular interactions of polysialic acid.
Polysialosyl chains containing alpha 2-8-linked N-acetylneuraminic acid have been suggested to modulate the biological activity… 
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