polycystin
National Institutes of Health
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It has been exciting times since the identification of polycystic kidney disease 1 (PKD1) and PKD2 as the genes mutated in…
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited human renal disease and is caused by mutations…
It is now clear that transient receptor potential (TRP) channels are sensors of temperature, mechanical force, noxious chemicals…
Mutations in either PKD1 or PKD2 gene are associated with autosomal dominant polycystic kidney disease, the most common inherited…
The sea urchin sperm acrosome reaction (AR) is a prerequisite for sperm-egg fusion. This report identifies sea urchin sperm…
The six‐transmembrane channels are thought to be composed of two modules: pore and sensor. Whereas the modular design of the pore…
Most patients with autosomal dominant polycystic kidney disease (ADPKD) harbor mutations truncating polycystin-1 (PC1) or…
Polycystins-1, -2, -L, and -REJ are the four known members of the polycystin family of proteins. In this study, we describe a…
Mutations in PKD1 cause autosomal dominant polycystic kidney disease (ADPKD), a common genetic disease in which cysts form from…
The gene PKD I, which is mutated in type I autosomal dominant polycystic kidney disease (ADPKD 1), encodes a large protein of…