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plinabulin

An orally active diketopiperazine derivative with potential antineoplastic activity. Plinabulin selectively targets and binds to the colchicine… 
National Institutes of Health

Related topics

Related topics

6 relations
Microtubule ProcessNCIt Antineoplastic Agent TerminologyNegative Regulation of MitosisPositive Regulation of Apoptosis

Broader (1)

NPI 2358

Papers overview

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2019
2019
A Randomized Phase 3 Clinical Trial of the Combination of Plinabulin (plin) + Pegfilgrastim (peg) Versus (vs) Peg Alone for Tac (docetaxel, doxorubicin, cyclophosphamide) Induced Neutropenia (cin)
Trial in Progress: Granulocyte colony stimulating factors (G-CSFs) (including Peg) reduce, but do not completely ameliorate CIN… 
Review
2018
Review
2018
Starvation tactics using natural compounds for advanced cancers: pharmacodynamics, clinical efficacy, and predictive biomarkers
The high mortality associated with oncological diseases is mostly due to tumors in advanced stages, and their management is a… 
2017
2017
Plinabulin as a novel small molecule clinical stage immuno-oncology agent for NSCLC.
139Background: Plinabulin (Plin) is a small molecule with tumor-inhibiting and immune-enhancing effects. In preclinical studies… 
2016
2016
Plinabulin, a Novel Small Molecule That Ameliorates Chemotherapy-Induced Neutropenia, Is Administered on the Same Day of Chemotherapy and Has Anticancer Efficacy
Plinabulin is a small molecule with tumor-inhibiting and immune-enhancing effects. Plinabulin induces dendritic cell maturation… 
2016
2016
The plinabulin/docetaxel combination to mitigate the known safety concerns of docetaxel.
e20595Background: Docetaxel is currently approved in non-small cell lung Cancer (NSCLC) after a failure of first line… 
2012
2012
Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents.
2011
2011
Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole.
2011
2011
Water-soluble prodrug of antimicrotubule agent plinabulin: effective strategy with click chemistry.
2010
2010
Phase II study of docetaxel with or without plinabulin (NPI-2358) in patients with non-small cell lung cancer (NSCLC).
7592 Background: Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) that acts on the cytoskeleton to destabilize tumor… 
2009
2009
Abstract C30: Phase 1/2 study of the vascular disrupting agent (VDA) plinabulin (NPI‐2358) combined with docetaxel in patients with non‐small cell lung cancer (NSCLC)
Background: Plinabulin is a vascular disrupting agent (VDA) that binds ‐ tubulin, destabilizing tumor vascular endothelial… 
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