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pleuromutilin

Known as: Drosophilin B, octahydro-5,8-dihydroxy-4,6,9,10- tetramethyl-6-vinyl-3a,9-propano-3aH-cyclopenta- cycloocten-1(4H)-one 8-glycolate, pleuromutilin [Chemical/Ingredient] 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Diterpenes
Pleuromutilin Antibacterial [EPC]retapamulin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia…
Monotherapy with lefamulin, a novel, pleuromutilin antibiotic with intravenous and oral formulation options, was noninferior to… 
Review
2017
Review
2017
Pleuromutilins: Potent Drugs for Resistant Bugs-Mode of Action and Resistance.
Pleuromutilins are antibiotics that selectively inhibit bacterial translation and are semisynthetic derivatives of the naturally… 
Review
2017
Review
2017
New and improved? A review of novel antibiotics for Gram-positive bacteria.
Highly Cited
2016
Highly Cited
2016
A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism
The increasing appearance of pathogenic bacteria with antibiotic resistance is a global threat. Consequently, clinically… 
Highly Cited
2011
Highly Cited
2011
New Transposon Tn6133 in Methicillin-Resistant Staphylococcus aureus ST398 Contains vga(E), a Novel Streptogramin A, Pleuromutilin, and Lincosamide Resistance Gene
ABSTRACT A novel streptogramin A, pleuromutilin, and lincosamide resistance determinant, Vga(E), was identified in porcine… 
Review
2010
Review
2010
The pleuromutilin antibiotics: a new class for human use.
Pleuromutilins were discovered as natural-product antibiotics in 1950. Tiamulin was the first pleuromutilin compound to be… 
Review
2009
Review
2009
Investigating pleuromutilin-producing Clitopilus species and related basidiomycetes.
Pleuromutilin is a broad-spectrum antibiotic that has been used in veterinary medicine for over 20 years, but is now gaining… 
Highly Cited
2007
Highly Cited
2007
Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity
New insights into functional flexibility at the peptidyl transferase center (PTC) and its vicinity were obtained by analysis of… 
Highly Cited
2004
Highly Cited
2004
Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin
Tiamulin, a prominent member of the pleuromutilin class of antibiotics, is a potent inhibitor of protein synthesis in bacteria… 
Highly Cited
1975
Highly Cited
1975
The mode of action of pleuromutilin derivatives. Location and properties of the pleuromutilin binding site on Escherichia coli ribosomes.
Using equilibrium dialysis techniques it could be demonstrated that (a) the pleuromutilin derivative 14-deoxy-14[(2… 
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