pladienolide B
National Institutes of Health
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The spliceosome is necessary for the removal of intron sequences in transcribed pre-mRNA in eukaryotic cells. More than 200…
Background: Diffuse malignant peritoneal mesothelioma (DMPM) is an aggressive tumor of the lining of the abdomen, characterized…
Trabalho final de mestrado integrado em Medicina (Hematologia/Biologia Molecular), apresentado a Faculdade de Medicina da…
Synthesis of C11-C23 fragment of an antitumor natural product, Pladienolide B, in gram-scale, is described. The key steps…
Targeting the spliceosome with small molecule inhibitors provides a new avenue to target cancer by intercepting alternate…
Abstract 3890 Alternative splicing plays a fundamental role in human biology and its relevance in cancer is rapidly emerging…
Pladienolide B and its 16-hydroxylated derivative (pladienolide D) are novel 12-membered macrolides produced by Streptomyces…