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plY protein, Streptococcus pneumoniae

Known as: pneumolysin 
National Institutes of Health

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2 relations

Broader (2)

Bacterial ProteinsStreptolysins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
The Cholesterol-Dependent Cytolysin Pneumolysin from Streptococcus pneumoniae Binds to Lipid Raft Microdomains in Human Corneal Epithelial Cells
Streptococcus pneumoniae (pneumococcus) is an opportunistic bacterial pathogen responsible for causing several human diseases… 
2005
2005
THP-1 Monocytes Up-Regulate Intercellular Adhesion Molecule 1 in Response to Pneumolysin from Streptococcus pneumoniae
ABSTRACT Pneumolysin (PLY) is a major virulence factor of Streptococcus pneumoniae that elicits a variety of proinflammatory… 
Highly Cited
2001
Highly Cited
2001
Structural Analysis of the Protein/Lipid Complexes Associated with Pore Formation by the Bacterial Toxin Pneumolysin*
Pneumolysin, a major virulence factor of the human pathogen Streptococcus pneumoniae, is a soluble protein that disrupts… 
Highly Cited
1998
Highly Cited
1998
Self-interaction of pneumolysin, the pore-forming protein toxin of Streptococcus pneumoniae.
The pathogenically important cholesterol-binding pore-forming bacterial "thiol-activated" toxins (TATs) are commonly believed to… 
Review
1997
Review
1997
Biological properties of pneumolysin.
Pneumolysin is a thiol-activated membrane-damaging toxin produced by Streptococcus pneumoniae. The toxin plays a role in… 
1996
1996
Passive and active immunotherapy for experimental pneumococcal pneumonia by polyvalent human immunoglobulin or F(ab')2 fragments administered intranasally.
Experimental pneumococcal pneumonia in leukopenic BALB/c mice enabled evaluation of passive immunotherapy with human polyvalent… 
Highly Cited
1994
Highly Cited
1994
Modeling the bacterial protein toxin, pneumolysin, in its monomeric and oligomeric form.
Highly Cited
1990
Highly Cited
1990
Demonstration of pneumolysin antibodies in circulating immune complexes - a new diagnoxtic method for pneumococcal pneumonia.
Highly Cited
1986
Highly Cited
1986
Inhibition of human monocyte respiratory burst, degranulation, phospholipid methylation and bactericidal activity by pneumolysin.
The interaction between the pneumococcal toxin pneumolysin and human monocytes was examined. At non-cytotoxic concentrations (0.5… 
Highly Cited
1947
Highly Cited
1947
COMPARATIVE KINETICS OF HEMOLYSIS INDUCED BY BACTERIAL AND OTHER HEMOLYSINS
A study has been made of the kinetics of lysis induced by various hemolytic agents. The course of bemolysis was followed by… 
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