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physical dependence

Known as: biological Alcohol or Other Drugs dependence, physiological addiction, biological AOD dependence 
The neuroadaptation of the body to the presence of an opioid, and is characterized by the onset of acute symptoms and signs of withdrawal if the… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Addictive BehaviorDrug Dependence

Narrower (1)

Narcotic Dependence
nervous system disorder

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
A Preliminary Review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Potential in Acute and Chronic Pain States
Various sections of the manuscript reviewed by: E. A.lo", Institut fUr Anasthesiologie, Universitiitsspital, Ziirich, Switzerland… 
Review
2008
Review
2008
Opioid complications and side effects.
Medications which bind to opioid receptors are increasingly being prescribed for the treatment of multiple and diverse chronic… 
Review
2005
Review
2005
Benzodiazepine use, abuse, and dependence.
Although benzodiazepines are invaluable in the treatment of anxiety disorders, they have some potential for abuse and may cause… 
Review
2005
Review
2005
Physical Interpersonal Relationships and Social Anxiety among Online Game Players
Many online game players spend inordinate amounts of time in their favorite virtual worlds. A large percentage of these players… 
Highly Cited
2004
Highly Cited
2004
A multiple motives approach to tobacco dependence: the Wisconsin Inventory of Smoking Dependence Motives (WISDM-68).
The dependence construct fills an important explanatory role in motivational accounts of smoking and relapse. Frequently used… 
Highly Cited
1999
Highly Cited
1999
Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice.
The function of the central cannabinoid receptor (CB1) was investigated by invalidating its gene. Mutant mice did not respond to… 
Highly Cited
1996
Highly Cited
1996
Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene
DESPITE tremendous efforts in the search for safe, efficacious and non-addictive opioids for pain treatment, morphine remains the… 
Highly Cited
1978
Highly Cited
1978
Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment.
Highly Cited
1971
Highly Cited
1971
Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels
Brain serotonin cocentrations at 1 p.m. were significantly elevated 1 hour after rats received a dose of L-tryptophan (12.5… 
Highly Cited
1969
Highly Cited
1969
Simultaneous quantitative assessment of morphine tolerance and physical dependence.
Subcutaneous implantation of a 75-mg tablet of morphine base in the back of a mouse results in measurable tolerance and physical… 
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