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Genome-wide search for genes affecting the risk for alcohol dependence.
There was suggestive evidence for a protective locus on chromosome 4 near the alcohol dehydrogenase genes, for which protective effects have been reported in Asian populations. Expand
Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations.
The very strong association of GABRA2 with both alcohol dependence and the beta frequency of the electroencephalogram, combined with biological evidence for a role of this gene in both phenotypes, suggest that GABra2 might influence susceptibility to alcohol dependence by modulating the level of neural excitation. Expand
Comparison of direct interview and family history diagnoses of alcohol dependence.
A recursive equation is derived to combine a variable number of family history reports, wherein the probabilities associated with a single report are computed from the logistic analysis, which permits the use offamily history information both as a proxy for an uninterviewed relative, as well as a second source of information to be used in the analysis of genetic family data. Expand
The utility of neurophysiological markers in the study of alcoholism
Quantitative neuroelectric measures (EEG, ERPs, EROs) provide valuable endophenotypes in the study of genetic risk to develop alcoholism and related disorders. Expand
Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism.
Alcohol, marijuana, and cocaine dependence and habitual smoking are all familial, and there is evidence of both common and specific addictive factors transmitted in families. Expand
Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis.
There was strong evidence that variations in ADH4 are associated with alcoholism: 12 SNPs were significantly associated and the region of strongest association ran from intron 1 to 19.5 kb beyond the 3' end of the gene. Expand
Association of the kappa-opioid system with alcohol dependence.
Genotyped SNPs throughout OPRK1, encoding the kappa-opioid receptor, and PDYN, which encodes its ligand prodynorphin, in a group of 1860 European American individuals from 219 multiplex alcohol dependent families and demonstrated associations between alcohol dependence and multiple SNPs in the promoter and 3' end of PDYN. Expand
S-transform time-frequency analysis of P300 reveals deficits in individuals diagnosed with alcoholism
OBJECTIVE Decomposition of event-related potential (ERP) waveforms using time-frequency representations (TFR's) is becoming increasingly common in electrophysiology. The P300 potential is anExpand
The Role of GABRA2 in Risk for Conduct Disorder and Alcohol and Drug Dependence across Developmental Stages
In a sample of children and adolescents ascertained as part of the COGA project, it is found that GABRA2 is significantly associated with childhood conduct disorder symptoms, but not with childhood alcohol dependence symptoms. Expand
A genome screen of maximum number of drinks as an alcoholism phenotype.
Evidence for linkage is in the region of the alcohol dehydrogenase gene cluster on chromosome 4, consistent with a prior report from COGA in which strictly defined nonalcoholic subjects in wave 1 were analyzed. Expand