phosphoribosyltransferase

 
National Institutes of Health

Papers overview

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2012
2012
Prodrug cancer gene therapy by mesenchymal stem cells (MSCs) targeted to tumors represents an attractive tool to activate… (More)
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2012
2012
BACKGROUND Inhibitors of nicotinamide phosphoribosyltransferase have recently been validated as therapeutic targets in leukemia… (More)
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Highly Cited
2011
Highly Cited
2011
OBJECTIVE Stroke is a leading cause of mortality and disability. Nicotinamide phosphoribosyltransferase (Nampt) is the rate… (More)
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Highly Cited
2009
Highly Cited
2009
Many metabolic and physiological processes display circadian oscillations. We have shown that the core circadian regulator, CLOCK… (More)
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Highly Cited
2009
Highly Cited
2009
RATIONALE NAD+ acts not only as a cofactor for cellular respiration but also as a substrate for NAD(+)-dependent enzymes, such as… (More)
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Highly Cited
2003
Highly Cited
2003
Activation of 5-fluorouracil into its nucleotides requires phosphorylation by three pathways involving orotate phosphoribosyl… (More)
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Highly Cited
2002
Highly Cited
2002
Yeast deprived of nutrients exhibit a marked life span extension that requires the activity of the NAD(+)-dependent histone… (More)
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Highly Cited
1999
Highly Cited
1999
DNA in somatic tissue is characterized by a bimodal pattern of methylation, which is established in the animal through a series… (More)
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1997
1997
Activation of gluatmine phosphoribosylpyrophosphate (RPPP) amidotransferase (GPATase) by binding of a PRPP substrate analog… (More)
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1997
1997
BACKGROUND Quinolinic acid (QA) is a neurotoxin and has been shown to be present at high levels in the central nervous system of… (More)
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