P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury.

Abstract

The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, before neuronal cell death occurs, in a rodent model of blast-mediated traumatic brain injury (TBI). This protective quality may be linked to… (More)
DOI: 10.1016/j.celrep.2014.08.030

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