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phosphonodifluoromethylphenylalanine

Known as: F(2)Pmp, F2-Pmp, phosphonodifluoromethylene phenylalanine 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Phenylalanine
analogs & derivatives

Papers overview

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2012
2012
A highly selective and potent PTP-MEG2 inhibitor with therapeutic potential for type 2 diabetes.
Protein tyrosine phosphatases (PTPs) constitute a large family of signaling enzymes that control the cellular levels of protein… 
Review
2006
Review
2006
Design and synthesis of phosphonodifluoromethyl phenylalanine (F2Pmp): a useful phosphotyrosyl mimetic.
  • T. Burke
  • Current Topics in Medicinal Chemistry
  • 2006
  • Corpus ID: 3018383
Hydrolytically-stable phosphotyrosyl (pTyr) mimetics can be useful tools for the study of cellular signal transduction processes… 
2005
2005
Unexpected relative aqueous solubilities of a phosphotyrosine analogue and two phosphonate derivatives.
Phosphotyrosine (pTyr) is an essential component of biological signaling, often being a determinant of protein-protein… 
2004
2004
Enantioselective Synthesis of (S)‐3‐Carboxy‐4‐((carboxy)difluoromethyl)phenylalanine in Protected Form and Its Incorporation into a PTP‐1B‐Directed Tripeptide
Recent findings have shown that, when expressed in the tripeptide platform, ‘Fmoc‐Glu‐Xxx‐Leu‐amide’, the phosphotyrosyl mimetic… 
Highly Cited
2003
Highly Cited
2003
The Role of C-terminal Tyrosine Phosphorylation in the Regulation of SHP-1 Explored via Expressed Protein Ligation*
The protein-tyrosine phosphatase SHP-1 plays a variety of roles in the “negative” regulation of cell signaling. The molecular… 
Highly Cited
2003
Highly Cited
2003
Chemical dissection of the effects of tyrosine phosphorylation of SHP-2.
The regulation of the protein tyrosine phosphatase (PTPase) SHP-2 by tyrosine phosphorylation has been difficult to elucidate… 
2003
2003
Tripeptide inhibitors of Yersinia protein-tyrosine phosphatase.
2002
2002
The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates.
Inhibitors of PTP-1B could be therapeutically beneficial in the treatment of type 2 diabetes. Owing to the large number of… 
2002
2002
The difluoromethylenesulfonic acid group as a monoanionic phosphate surrogate for obtaining PTP1B inhibitors.
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