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phosphonodifluoromethylphenylalanine
Known as:
F(2)Pmp
, F2-Pmp
, phosphonodifluoromethylene phenylalanine
National Institutes of Health
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Related topics
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2 relations
Broader (1)
Phenylalanine
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
A highly selective and potent PTP-MEG2 inhibitor with therapeutic potential for type 2 diabetes.
S. Zhang
,
Sijiu Liu
,
+8 authors
Zhon-Yin Zhang
Journal of the American Chemical Society
2012
Corpus ID: 24260635
Protein tyrosine phosphatases (PTPs) constitute a large family of signaling enzymes that control the cellular levels of protein…
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Review
2006
Review
2006
Design and synthesis of phosphonodifluoromethyl phenylalanine (F2Pmp): a useful phosphotyrosyl mimetic.
T. Burke
Current Topics in Medicinal Chemistry
2006
Corpus ID: 3018383
Hydrolytically-stable phosphotyrosyl (pTyr) mimetics can be useful tools for the study of cellular signal transduction processes…
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2005
2005
Unexpected relative aqueous solubilities of a phosphotyrosine analogue and two phosphonate derivatives.
S. Boresch
,
Martin Leitgeb
,
A. Beselman
,
Alexander D. MacKerell
Journal of the American Chemical Society
2005
Corpus ID: 23396675
Phosphotyrosine (pTyr) is an essential component of biological signaling, often being a determinant of protein-protein…
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2004
2004
Enantioselective Synthesis of (S)‐3‐Carboxy‐4‐((carboxy)difluoromethyl)phenylalanine in Protected Form and Its Incorporation into a PTP‐1B‐Directed Tripeptide
Sang-Uk Kang
,
Yang Gao
,
Li Wu
,
Zhon-Yin Zhang
,
T. Burke
Chemistry and Biodiversity
2004
Corpus ID: 21177320
Recent findings have shown that, when expressed in the tripeptide platform, ‘Fmoc‐Glu‐Xxx‐Leu‐amide’, the phosphotyrosyl mimetic…
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Highly Cited
2003
Highly Cited
2003
The Role of C-terminal Tyrosine Phosphorylation in the Regulation of SHP-1 Explored via Expressed Protein Ligation*
Zhongsen Zhang
,
Kui Shen
,
W. Lu
,
P. Cole
Journal of Biological Chemistry
2003
Corpus ID: 39322148
The protein-tyrosine phosphatase SHP-1 plays a variety of roles in the “negative” regulation of cell signaling. The molecular…
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Highly Cited
2003
Highly Cited
2003
Chemical dissection of the effects of tyrosine phosphorylation of SHP-2.
W. Lu
,
Kui Shen
,
P. Cole
Biochemistry
2003
Corpus ID: 21446322
The regulation of the protein tyrosine phosphatase (PTPase) SHP-2 by tyrosine phosphorylation has been difficult to elucidate…
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2003
2003
Tripeptide inhibitors of Yersinia protein-tyrosine phosphatase.
Kyeong Lee
,
Yang Gao
,
+6 authors
T. Burke
Bioorganic & Medicinal Chemistry Letters
2003
Corpus ID: 16939352
2002
2002
The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates.
E. Asante-Appiah
,
Sangita Patel
,
+9 authors
G. Scapin
Biochemistry
2002
Corpus ID: 23637440
Inhibitors of PTP-1B could be therapeutically beneficial in the treatment of type 2 diabetes. Owing to the large number of…
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2002
2002
The difluoromethylenesulfonic acid group as a monoanionic phosphate surrogate for obtaining PTP1B inhibitors.
Carmen Leung
,
J. Grzyb
,
+5 authors
Scott D. Taylor
Bioorganic & Medicinal Chemistry
2002
Corpus ID: 25507055
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