FAQ

phosphonodifluoromethylphenylalanine

Known as: F(2)Pmp, F2-Pmp, phosphonodifluoromethylene phenylalanine 
 

Topic mentions per year

Topic mentions per year

2002-2012
0120022012

Related topics

Related topics

1 relation

Broader (1)

Phenylalanine

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
phosphonodifluoromethylphenylalanine
Phenylalanine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
A highly selective and potent PTP-MEG2 inhibitor with therapeutic potential for type 2 diabetes.
Protein tyrosine phosphatases (PTPs) constitute a large family of signaling enzymes that control the cellular levels of protein… (More)
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?
Review
2006
Review
2006
Design and synthesis of phosphonodifluoromethyl phenylalanine (F2Pmp): a useful phosphotyrosyl mimetic.
Hydrolytically-stable phosphotyrosyl (pTyr) mimetics can be useful tools for the study of cellular signal transduction processes… (More)
Is this relevant?
2005
2005
Unexpected relative aqueous solubilities of a phosphotyrosine analogue and two phosphonate derivatives.
Phosphotyrosine (pTyr) is an essential component of biological signaling, often being a determinant of protein-protein… (More)
Is this relevant?
2004
2004
Enantioselective synthesis of (S)-3-carboxy-4-((carboxy)difluoromethyl)phenylalanine in protected form and its incorporation into a PTP-1B-directed tripeptide.
Recent findings have shown that, when expressed in the tripeptide platform, 'Fmoc-Glu-Xxx-Leu-amide', the phosphotyrosyl mimetic… (More)
Is this relevant?
2003
2003
The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation.
The protein-tyrosine phosphatase SHP-1 plays a variety of roles in the "negative" regulation of cell signaling. The molecular… (More)
Is this relevant?
2003
2003
Chemical dissection of the effects of tyrosine phosphorylation of SHP-2.
The regulation of the protein tyrosine phosphatase (PTPase) SHP-2 by tyrosine phosphorylation has been difficult to elucidate… (More)
Is this relevant?
2003
2003
Tripeptide inhibitors of Yersinia protein-tyrosine phosphatase.
The protein-tyrosine phosphatase (PTP) 'YopH' is a virulence factor of Yersinia pestis, the causative agent of plague. Potential… (More)
  • figure 1
  • table 1
  • figure 2
Is this relevant?
2002
2002
The difluoromethylenesulfonic acid group as a monoanionic phosphate surrogate for obtaining PTP1B inhibitors.
Three peptides, 7-9, bearing sulfono(difluoromethyl)phenylalanine (F(2)Smp, 2), a nonhydrolyzable, monoanionic phosphotyrosine… (More)
Is this relevant?