FAQ

phospholipase A2, group X protein

Known as: Group X Secretory Phospholipase A(2), Phospholipases A2, Group X, sPLA2-X 
A secreted phospholipase A2 subtype that contains a interfacial-binding region with specificity for PHOSPHATIDYLCHOLINE. This enzyme group may play a… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2017
024619992017

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9 relations
In BloodProcess of secretionadministration & dosageantagonists & inhibitors
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
phospholipase A2, group X protein
physiological aspects
chemical synthesis
standards characteristics
Process of secretion
In Blood

Papers overview

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2010
2010
Eosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X.
Secreted phospholipase A(2) group X (sPLA(2)-X) has recently been identified in the airways of patients with asthma and may… (More)
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2010
2010
Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages.
OBJECTIVE GX sPLA(2) potently hydrolyzes plasma membranes to generate lysophospholipids and free fatty acids; it has been… (More)
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2008
2008
Reduction in myocardial ischemia/reperfusion injury in group X secretory phospholipase A2-deficient mice.
BACKGROUND Group X secretory phospholipase A(2) (sPLA(2)-X) has the most potent hydrolyzing activity toward phosphatidylcholine… (More)
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2007
2007
Secreted phospholipase A2 group X overexpression in asthma and bronchial hyperresponsiveness.
RATIONALE Secreted phospholipase A(2) enzymes (sPLA(2)s) play key regulatory roles in the biosynthesis of eicosanoids, such as… (More)
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Highly Cited
2007
Highly Cited
2007
Importance of group X–secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model
Arachidonic acid metabolites, the eicosanoids, are key mediators of allergen-induced airway inflammation and remodeling in asthma… (More)
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2006
2006
Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction.
In an effort to elucidate the functions of secreted phospholipase A2 (sPLA2) enzymes in vivo, we generated transgenic (Tg) mice… (More)
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2005
2005
Neuronal expression and neuritogenic action of group X secreted phospholipase A2.
Although individual mammalian secreted phospholipase A(2) (sPLA(2)) enzymes exhibit unique tissue and cellular distributions, the… (More)
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2005
2005
Diverse cellular localizations of secretory phospholipase A2 enzymes in several human tissues.
The secretory phospholipase A2 (sPLA2) family in mammals contains more than 10 enzymes. In this study, we examined by… (More)
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2002
2002
Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis.
The bacterial tripeptide formyl-Met-Leu-Phe (fMLP) induces the secretion of enzyme(s) with phospholipase A(2) (PLA(2)) activity… (More)
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2000
2000
Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor.
Group X secretory phospholipase A2 (sPLA2-X) has recently been shown to possess a powerful potency for releasing arachidonic acid… (More)
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