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phenoxodiol

Known as: 2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl), Idronoxil, 7-hydroxy-3-hydroxyphenyl-1H-benzopyran 
A synthetic flavonoid derivative. Idronoxil activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis (XIAP), and disrupts… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Isoflavones
NCIt Antineoplastic Agent Terminology

Narrower (1)

NV-06

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Pharmacology of ME‐344, a novel cytotoxic isoflavone
2019
2019
Synthetic lethality guiding selection of drug combinations in ovarian cancer
Background Synthetic lethality describes a relationship between two genes where single loss of either gene does not trigger… 
2011
2011
Phase II Evaluation of Phenoxodiol in Combination With Cisplatin or Paclitaxel in Women With Platinum/Taxane-Refractory/Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers
Introduction: Chemoresistance is a major limitation in the treatment of ovarian cancer. Phenoxodiol is a novel biomodulator… 
2010
2010
Phenoxodiol inhibits growth of metastatic prostate cancer cells
Phenoxodiol, a synthetic analog of Genistein, is being assessed in several clinical studies against a range of cancer types and… 
Highly Cited
2008
Highly Cited
2008
Reversal of drug resistance in ovarian cancer: where do we go from here?
Disease management in patients with ovarian cancer exemplifies the fundamental problem underlying much of today’s cancer… 
2008
2008
Phenoxodiol—A Chemosensitizer in the Midst of Cancer Chemoresistance
Phenoxodiol ([2H-1-Benzopyran-7-ol, 3-(4-hydrophyphenyl] (PXD) is a synthetic derivative of genistein, a naturally occurring… 
Review
2008
Review
2008
Modulation of apoptosis to reverse chemoresistance.
Interference with the innate apoptotic activity is a hallmark of neoplastic transformation and tumor formation. Modulation of the… 
2007
2007
Phenoxodiol-topotecan co-administration exhibit significant anti-tumor activity without major adverse side effects
Objective: We previously showed that Phenoxodiol is able to sensitize epithelial ovarian cancer cells to Paclitaxel, Carboplatin… 
2005
2005
Growth of LNCaP cells in monoculture and coculture with osteoblasts and response to tNOX inhibitors.
Highly Cited
2004
Highly Cited
2004
X-linked inhibitor of apoptosis (XIAP) confers human trophoblast cell resistance to Fas-mediated apoptosis.
Apoptosis occurs in the placenta throughout gestation, with a greater frequency near term in comparison to the first trimester… 
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