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petroleum alkylate

National Institutes of Health

Papers overview

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2008
2008
1,1‐bis(3′‐indolyl)‐1‐(p‐substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines
1,1‐Bis(3′‐indolyl)‐1‐(p‐substituted phenyl)methanes, containing p‐t‐butyl (DIM‐C‐pPhtBu) and phenyl (DIM‐C‐pPhC6H5) substituents… 
2000
2000
Region-specific DNA damage by AT-specific DNA-reactive drugs is predicted by drug binding specificity.
Bizelesin and adozelesin are DNA-reactive antitumor drugs that alkylate adenines at the 3' ends of their preferred binding sites… 
1998
1998
Synthesis of new bifunctional compounds which selectively alkylate guanines in DNA.
The aim of this work was to develop new bifunctional alkylating agents which damage DNA in a selective manner. In order to extend… 
1997
1997
Expression of the O6-alkylguanine-DNA alkyltransferase gene is elevated in human breast tumor cells.
In tumors, resistance to chemotherapeutic drugs that alkylate the O6 position of guanine correlates with the levels of the DNA… 
1995
1995
Sequence-specific DNA interactions by novel alkylating anthracycline derivatives.
New alkylating anthracycline derivatives with promising antitumor activity have been synthesized. We selected two of these… 
1987
1987
Affinity-labelling of the anti-inflammatory drug and prostaglandin-binding site of 3 alpha-hydroxysteroid dehydrogenase of rat liver cytosol with 17 beta- and 21-bromoacetoxysteroids.
The homogeneous 3 alpha-hydroxysteroid dehydrogenase of rat liver cytosol binds prostaglandins with low micromolar affinity at… 
1985
1985
An intramolecular cross-linkage of lysozyme. Formation of cross-links between lysine-1 and histidine-15 with bis(bromoacetamide) derivatives by a two-stage reaction procedure and properties of the…
Hen egg white lysozyme was treated at pH 5.5 with four bifunctional reagents, bis(bromoacetamide) derivatives [BrCH2CONH(CH2… 
1979
1979
Mechanism of action of 2-haloethylnitrosoureas on deoxyribonucleic acid. Nature of the chemical reactions with deoxyribonucleic acid.
1968
1968
Metabolism of linear alkylate sufonate and alkyl benzene sulfonate in albino rats.
1965
1965
NEW METHOD FOR DETERMINATION OF ALKYLATING AGENTS IN BIOLOGIC FLUIDS.
An accurate, reproducible colorimetric method for determining minute amounts of alkylating agents in biologic fluids has been… 
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