FAQ

peripheral tolerance induction

Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues. [GO_REF:0000022, GOC:jal… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2016
02419922016

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Highly Cited
2013
Highly Cited
2013
Specialized role of migratory dendritic cells in peripheral tolerance induction.
Harnessing DCs for immunotherapies in vivo requires the elucidation of the physiological role of distinct DC populations… (More)
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2007
2007
Cognate CD4+ help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8+ T cells.
Peripheral tolerance is required to prevent autoimmune tissue destruction by self-reactive T cells that escape negative selection… (More)
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Highly Cited
2007
Highly Cited
2007
Rapamycin, not cyclosporine, permits thymic generation and peripheral preservation of CD4+CD25+FoxP3+ T cells
Graft-versus-host-disease (GVHD) is the most common cause of poor outcome after allogeneic stem cell transplantation (SCT). Of… (More)
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2007
2007
Programmed cell death 1 (PD-1) and its ligand PD-L1 are required for allograft tolerance.
Programmed cell death-1 (PD-1, CD279) and its widely expressed, inducible ligand, PD-L1 (CD274), together dampen T cell… (More)
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2003
2003
CD28 Costimulation Is Required for In Vivo Induction of Peripheral Tolerance in CD8 T Cells
Whereas ligation of CD28 is known to provide a critical costimulatory signal for activation of CD4 T cells, the requirement for… (More)
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Highly Cited
2001
Highly Cited
2001
Generation of anergic and potentially immunoregulatory CD25+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen.
Immunoregulatory CD25(+)CD4 T cells are thought to arise from the thymus as a distinct lineage of CD4 T cells specific for self… (More)
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Highly Cited
1999
Highly Cited
1999
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
The mechanisms of allograft tolerance have been classified as deletion, anergy, ignorance and suppression/regulation. Deletion… (More)
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1999
1999
Ontogeny of T cell tolerance to peripherally expressed antigens.
Transgenic expression of the influenza virus hemagglutinin (HA) in the pancreatic islet beta cells of InsHA mice leads to… (More)
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Highly Cited
1994
Highly Cited
1994
Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.
An adoptive transfer system was used to monitor physically the behavior of a trace population of TCR transgenic T cells in vivo… (More)
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Highly Cited
1992
Highly Cited
1992
Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen.
Self-reactive T lymphocytes escaping thymic tolerance induction can be rendered non-responsive by contact with antigens in the… (More)
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