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perillic acid

Known as: 4-(1-methylethenyl)-1-cyclohexene-1-carboxylic acid, 4-Isopropenylcyclohex-1-enecarboxylic Acid, 4-(2-propenyl)-1-cyclohexane-1-carboxylic acid 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

CyclohexenesMonoterpenes

Papers overview

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Highly Cited
2005
Highly Cited
2005
Effect of D-limonene on immune response in BALB/c mice with lymphoma.
Highly Cited
2002
Highly Cited
2002
Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression.
2002
2002
Pharmacokinetics of perillic acid in humans after a single dose administration of a citrus preparation rich in d-limonene content.
d-Limonene, a monoterpene, is widely distributed as a natural nonnutritive constituent of a variety of foods and volatile oils… 
Highly Cited
2000
Highly Cited
2000
Phase I clinical and pharmacokinetic study of perillyl alcohol administered four times a day.
We conducted a phase I dose-escalation trial of perillyl alcohol (POH; NSC 641066) given p.o. on a continuous four times a day… 
Highly Cited
2000
Highly Cited
2000
Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refractory solid malignancies.
Perillyl alcohol (POH) is a monoterpene with anticarcinogenic and antitumor activity in murine tumor models. Putative mechanisms… 
Highly Cited
1999
Highly Cited
1999
Blocking signaling through the gp130 receptor chain by interleukin‐6 and oncostatin M inhibits PC‐3 cell growth and sensitizes the tumor cells to etoposide and cisplatin‐mediated cytotoxicity
The mechanisms of drug resistance associated with advanced, hormone‐independent prostate carcinoma are poorly understood. The… 
Highly Cited
1999
Highly Cited
1999
Inhibition of protein prenylation by metabolites of limonene.
1997
1997
Perillic acid inhibits Ras/MAP kinase-driven IL-2 production in human T lymphocytes.
Perillic acid, a major metabolite of d-limonene, substantially suppressed interleukin-2 (IL-2) and IL-10 production in mitogen… 
Highly Cited
1995
Highly Cited
1995
Isoprenylation of proteins in the protozoan Giardia lamblia.
Highly Cited
1991
Highly Cited
1991
Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites.
Limonene has chemotherapeutic activity against chemically induced rat mammary carcinomas, many of which contain activated ras… 
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