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perillic acid

Known as: 4-(1-methylethenyl)-1-cyclohexene-1-carboxylic acid, 4-Isopropenylcyclohex-1-enecarboxylic Acid, 4-(2-propenyl)-1-cyclohexane-1-carboxylic acid 
 
National Institutes of Health

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2 relations

Broader (2)

CyclohexenesMonoterpenes

Papers overview

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Highly Cited
2007
Highly Cited
2007
Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells.
Plant products such as perillyl alcohol have been reported to possess anti-tumor activities against a number of human cancers… Expand
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2003
2003
Immunomodulatory Activity of Naturally Occurring Monoterpenes Carvone, Limonene, and Perillic Acid
The immunomodulatory activity of some naturally occurring monoterpenes were studied in Balb/c mice. Administration of various… Expand
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2003
2003
Effect of naturally occurring monoterpenes carvone, limonene and perillic acid in the inhibition of experimental lung metastasis induced by B16F-10 melanoma cells.
The effects of naturally occurring monoterpenes on lung metastasis induced by B16F-10 melanoma cells were studied in C57BL/6 mice… Expand
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2002
2002
Pharmacokinetics of perillic acid in humans after a single dose administration of a citrus preparation rich in d-limonene content.
d-Limonene, a monoterpene, is widely distributed as a natural nonnutritive constituent of a variety of foods and volatile oils… Expand
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2001
2001
Bioconversion of limonene to increased concentrations of perillic acid by Pseudomonas putida GS1 in a fed-batch reactor
Abstract. Pseudomonas putida GS1 is able to convert limonene to perillic acid (up to 64 mM,(11 g/l) when the bacteria is… Expand
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2000
2000
Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refractory solid malignancies.
Perillyl alcohol (POH) is a monoterpene with anticarcinogenic and antitumor activity in murine tumor models. Putative mechanisms… Expand
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Highly Cited
1998
Highly Cited
1998
3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture.
Recent evidence suggests that apoptosis may be involved in the control of vascular smooth muscle cell (VSMC) number in… Expand
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Highly Cited
1998
Highly Cited
1998
Phase I and pharmacokinetic study of d-limonene in patients with advanced cancer
Purpose: d-Limonene is a natural monoterpene with pronounced chemotherapeutic activity and minimal toxicity in preclinical… Expand
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1997
1997
Perillic acid inhibits Ras/MAP kinase-driven IL-2 production in human T lymphocytes.
Perillic acid, a major metabolite of d-limonene, substantially suppressed interleukin-2 (IL-2) and IL-10 production in mitogen… Expand
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Highly Cited
1991
Highly Cited
1991
Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites.
Limonene has chemotherapeutic activity against chemically induced rat mammary carcinomas, many of which contain activated ras… Expand
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