perifosine

Known as: Octadecyl-(N,N-dimethylpiperidino-4-yl)phosphate, Octadecylphosphopiperidine, 4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethylpiperidinium, Inner Salt 
An orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway mediates multiple myeloma (MM) cell… (More)
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Highly Cited
2009
Highly Cited
2009
Perifosine is an alkylphospholipid exhibiting antitumor activity as shown in both preclinical studies and clinical trials. This… (More)
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Highly Cited
2008
Highly Cited
2008
A significant impediment to the success of cancer chemotherapy is the occurrence of multidrug resistance, which, in many cases… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE It is critical to develop methods to quantify the early pharmacodynamic effects of targeted therapeutics in vivo to make… (More)
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Highly Cited
2007
Highly Cited
2007
Multiple myeloma (MM) is an incurable B-cell malignancy, requiring new therapeutic strategies. We have found that synthetic alkyl… (More)
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Highly Cited
2006
Highly Cited
2006
Perifosine is a synthetic novel alkylphospholipid, a new class of antitumor agents which targets cell membranes and inhibits Akt… (More)
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Highly Cited
2005
Highly Cited
2005
Interactions between histone deacetylase inhibitors (HDACIs) and the alkyl-lysophospholipid perifosine were examined in human… (More)
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Highly Cited
2005
Highly Cited
2005
Perifosine is an oral Akt inhibitor which exerts a marked cytotoxic effect on human tumor cell lines, and is currently being… (More)
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Highly Cited
2003
Highly Cited
2003
Perifosine is a novel p.o. bioavailable alkylphospholipid. Perifosine has displayed significant antiproliferative activity in… (More)
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Highly Cited
2002
Highly Cited
2002
Alkylphosphocholines are a novel class of antitumour agents structurally related to ether lipids that interact with the cell… (More)
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