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perifosine

Known as: Octadecyl-(N,N-dimethylpiperidino-4-yl)phosphate, Octadecylphosphopiperidine, 4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethylpiperidinium, Inner Salt 
An orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane… 
National Institutes of Health

Related topics

Related topics

8 relations

Narrower (1)

D 21266
Impaired Cell Membrane IntegrityNCIt Antineoplastic Agent TerminologyPhospholipid BindingPlasma membrane

Broader (1)

Phosphorylcholine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Lipid rafts, endoplasmic reticulum and mitochondria in the antitumor action of the alkylphospholipid analog edelfosine.
The so-called alkylphospholipid analogs (APLs) constitute a family of synthetic antitumor compounds that target cell membranes… 
2012
2012
Lipid molecules induce p38α activation via a novel molecular switch.
2009
2009
Antitumor Alkyl Ether Lipid Edelfosine: Tissue Distribution and Pharmacokinetic Behavior in Healthy and Tumor-Bearing Immunosuppressed Mice
Purpose: The present study investigates and compares the dose-dependent pharmacokinetics and oral bioavailability of edelfosine… 
2008
2008
Perifosine Synergistically Enhances TRAIL-Induced Myeloma Cell Apoptosis via Up-Regulation of Death Receptors
Purpose: The aim of this study is to investigate the efficacy of a novel Akt inhibitor, perifosine, in combination with tumor… 
Review
2007
Review
2007
Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy.
2007
2007
Lipid rafts and metabolic energy differentially determine uptake of anti-cancer alkylphospholipids in lymphoma versus carcinoma cells.
Highly Cited
2007
Highly Cited
2007
Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells
Akt mediates growth and drug resistance in multiple myeloma (MM) cells in the bone marrow (BM) microenvironment. We have shown… 
Highly Cited
2006
Highly Cited
2006
Phase II study of daily oral perifosine in patients with advanced soft tissue sarcoma
A multicenter Phase II study was performed to evaluate the clinical activity of an initial loading (150 mg every 6 hours × 4… 
Highly Cited
2006
Highly Cited
2006
Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells
Akt has been implicated as a molecular determinant of cellular radiosensitivity. Because it is often constitutively activated or… 
Highly Cited
2005
Highly Cited
2005
Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and…
Interactions between histone deacetylase inhibitors (HDACIs) and the alkyl-lysophospholipid perifosine were examined in human… 
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