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perifosine

Known as: Octadecyl-(N,N-dimethylpiperidino-4-yl)phosphate, Octadecylphosphopiperidine, 4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethylpiperidinium, Inner Salt 
An orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane… 
National Institutes of Health

Related topics

Related topics

8 relations

Narrower (1)

D 21266
Impaired Cell Membrane IntegrityNCIt Antineoplastic Agent TerminologyPhospholipid BindingPlasma membrane

Broader (1)

Phosphorylcholine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Taurine Promotes Neuritic Growth of Dorsal Root Ganglion Cells Exposed to High Glucose in Vitro.
Diabetic neuropathy (DN) is the most common chronic complication of DM and its major pathological changes show axonal dysfunction… 
2018
2018
The study of perifosine in colorectal carcinoma spheroids by MALDI TOF MSI and confocal microscopy
In our study, the spheroids derived from colorectal carcinoma and potential cancerostatic perifosine were studied. The cellular… 
2015
2015
GD 2 ganglioside specific antibody treatment downregulates PI 3 K / Akt / mTOR signaling network in human neuroblastoma cell lines
Mechanisms leading to inhibitory effects of an anti-GD2 ganglioside (GD2) 14G2a mouse monoclonal antibody (mAb) and PI3K/Akt/mTOR… 
2013
2013
Phase III Trial of Perifosine in Multiple Myeloma Halted
An ongoing phase III study comparing the efficacy and safety of perifosine in patients with relapsed or relapsed/refractory… 
2013
2013
Simultaneous Inhibition of the Raf/MEK/ERK and PI3K/Atk/mTOR Pathways has Significant Synergistic Effects on Proliferation and Migration in C6 Glioma Cancer Cells
The effect of combining Raf/ERK pathway inhibitors with PI3K/mTOR pathway inhibitors in C6 glioma brain cancer cells was studied… 
2012
2012
The Akt Inhibitor MK 2206 Synergizes , but Perifosine Antagonizes , the BRAFV 600 E Inhibitor PLX 4032 and the MEK 1 / 2 Inhibitor AZD 6244 in the Inhibition of Thyroid Cancer Cells
Results: We found that MK2206 could potently, when used alone, and synergistically, when combined with either PLX4032 or AZD6244… 
2011
2011
Interaction of Alkylphospholipid Formulations with Breast Cancer Cells in the Context of Anticancer Drug Development
Alkylphospholipids have shown promising results in several clinical studies (Mollinedo 2007) and among them Perifosine (octadecyl… 
2010
2010
Safety and pharmacokinetic (PK) study of perifosine plus capecitabine (P-CAP) in patients (pts) with refractory metastatic colorectal cancer (mCRC).
e14086 Background: Perifosine (P), a synthetic alkylphospholipid, inhibits or modifies multiple signal transduction pathways… 
2008
2008
Phase I multicenter trial of perifosine in combination with sorafenib for patients with advanced cancers including renal cell carcinoma
16024 Background: Perifosine (PERI) is an oral alkylphosphocholine with effects on multiple pathways including Akt, MAPK and JNK… 
2007
2007
PharmacodynamicMarkers of Perifosine Efficacy
Purpose: It is critical to develop methods to quantify the early pharmacodynamic effects of targeted therapeutics in vivo to make…