Share This Author
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.
Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC
Durvalumab therapy resulted in significantly longer overall survival than placebo, and no new safety signals were identified.
Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells.
Redundant Akt activation by nicotine and NNK could contribute to tobacco-related carcinogenesis by regulating two processes critical for tumorigenesis, cell growth and apoptosis.
Durvalumab after Chemoradiotherapy in Stage III Non–Small‐Cell Lung Cancer
Progression‐free survival was significantly longer with durvalumab than with placebo, and safety was similar between the groups, and the secondary end points also favored durvalsumab.
PTEN loss in the continuum of common cancers, rare syndromes and mouse models
StudyingPTEN in the continuum of rare syndromes, common cancers and mouse models provides insight into the role of PTEN in tumorigenesis and will inform targeted drug development.
Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations.
Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.
Binding to the cation-independent Man-6-P/insulin-like growth factor type II receptor appears to be a requirement for activation of LTGF-beta.
Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo
Nelfinavir is a lead HIV protease inhibitor with pleiotropic effects in cancer cells and is a Food and Drug Administration–approved drug that could be repositioned as a cancer therapeutic.
Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis
- R. Memmott, Jose Mercado, C. R. Maier, S. Kawabata, S. Fox, P. Dennis
- Medicine, BiologyCancer Prevention Research
- 1 September 2010
It is shown that metformin prevents tobacco carcinogen–induced lung tumorigenesis and support clinical testing of met formin as a chemopreventive agent.