• Publications
  • Influence
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented. Expand
Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC
Durvalumab therapy resulted in significantly longer overall survival than placebo, and no new safety signals were identified. Expand
Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells.
Redundant Akt activation by nicotine and NNK could contribute to tobacco-related carcinogenesis by regulating two processes critical for tumorigenesis, cell growth and apoptosis. Expand
Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations.
This review will provide an update on the clinical progress of various agents that target the PI3K/Akt/mTOR pathway and discuss strategies to combine these pathway inhibitors with conventional chemotherapy, radiotherapy, as well as newer targeted agents. Expand
PTEN loss in the continuum of common cancers, rare syndromes and mouse models
StudyingPTEN in the continuum of rare syndromes, common cancers and mouse models provides insight into the role of PTEN in tumorigenesis and will inform targeted drug development. Expand
Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.
  • P. Dennis, D. Rifkin
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 15 January 1991
Binding to the cation-independent Man-6-P/insulin-like growth factor type II receptor appears to be a requirement for activation of LTGF-beta. Expand
Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis
It is shown that metformin prevents tobacco carcinogen–induced lung tumorigenesis and support clinical testing of met formin as a chemopreventive agent. Expand
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
In this review, small molecules designed to specifically target Akt and other components of the PI3K/Akt pathway are now being developed for clinical use as single agents and in combination with chemotherapy to overcome therapeutic resistance. Expand
Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors
Combined blockade of the EGFR tyrosine kinase and Akt should be considered as a therapeutic approach in EGFR-expressing tumor cells with concomitant amplification(s) of PI3K-Akt signaling. Expand
Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo
Nelfinavir is a lead HIV protease inhibitor with pleiotropic effects in cancer cells and is a Food and Drug Administration–approved drug that could be repositioned as a cancer therapeutic. Expand