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perforin production

The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or… 
National Institutes of Health

Papers overview

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Highly Cited
2019
Highly Cited
2019
Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies
BackgroundTriple-negative breast cancer (TNBC) treatment is currently restricted to chemotherapy. Hence, tumor-specific molecular… 
2018
2018
Hepatitis C virus core protein reduces CD8+ T‐cell proliferation, perforin production and degranulation but increases STAT5 activation
Clearance of hepatitis C virus (HCV) is dependent on an effective virus‐specific CD8+ T‐cell response, which is dysfunctional in… 
2014
2014
CD160 expression defines a uniquely exhausted subset of T lymphocytes in HTLV-1 infection.
2014
2014
Jak/STAT and PI3K signaling pathways have both common and distinct roles in IL‐7‐mediated activities in human CD8+ T cells
IL‐7 plays an important role in T cell survival, function, and memory cell development, yet the role of cytokine signaling… 
2012
2012
AKT/SGK-sensitive phosphorylation of GSK3 in the regulation of L-selectin and perforin expression as well as activation induced cell death of T-lymphocytes.
2007
2007
Exogenous IL-10 overexpression reduces perforin production by activated allogenic CD8+ cells and prolongs cardiac allograft survival.
Perforin is a cytolytic mediator produced by cytotoxic T cells (CD8(+) cells) and natural killer cells. We previously reported… 
2005
2005
Paclitaxel probably enhances cytotoxicity of natural killer cells against breast carcinoma cells by increasing perforin production
Paclitaxel, a semisynthetic taxane, is one of the most active chemotherapeutic agents for the treatment of patients with breast… 
2005
2005
Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis
CD3+CD4+CD28null and CD3+CD8+CD28null T cells are enriched in patients with immune-mediated diseases compared with healthy… 
2003
2003
Assessment of cell mediated immunogenicity of Mycobacterium leprae-derived antigens.
Highly Cited
2000
Highly Cited
2000
Human CD8+ T Cells Specific forMycobacterium tuberculosis Secreted Antigens in Tuberculosis Patients and Healthy BCG-Vaccinated Controls in The Gambia
ABSTRACT Intracellular flow cytometry analysis of perforin production by CD8+ T cells showed levels were greatly reduced in… 
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