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paxillin

Known as: PXN, Paxillin [Chemical/Ingredient] 
Paxillin is a signal transducing adaptor protein that localizes to FOCAL ADHESIONS via its four LIM domains. It undergoes PHOSPHORYLATION in response… 
National Institutes of Health

Related topics

Related topics

28 relations
Adaptor Proteins, Signal TransducingAdaptor Signaling Protein GeneAgrin PathwayAngiogenesis Pathway

Broader (2)

CalmodulinCell Adhesion Molecules

Papers overview

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2012
2012
Ethanol suppresses phagosomal adhesion maturation, Rac activation, and subsequent actin polymerization during FcγR-mediated phagocytosis.
Highly Cited
2011
Highly Cited
2011
Steroid receptor coactivator-1 upregulates integrin α₅ expression to promote breast cancer cell adhesion and migration.
Metastatic breast cancer remains a lethal disease with poorly understood molecular mechanisms. Steroid receptor coactivator-1… 
2010
2010
Leupaxin is similar to paxillin in focal adhesion targeting and tyrosine phosphorylation but has distinct roles in cell adhesion and spreading
Focal adhesion (FA) formation is induced by extracellular matrix-stimulated integrin clustering and activation of receptors for… 
2006
2006
Extracellular pressure stimulates tumor cell adhesion in vitro by paxillin activation
Metastasizing colon cancer cells bind target tissues primarily via integrins. Extracellular pressure or shear stress stimulates… 
2000
2000
Role of Rho in Ca(2+)-insensitive contraction and paxillin tyrosine phosphorylation in smooth muscle.
We investigated whether Rho activation is required for Ca(2+)-insensitive paxillin phosphorylation, myosin light chain (MLC… 
Highly Cited
1999
Highly Cited
1999
Mechanosensitive tyrosine phosphorylation of paxillin and focal adhesion kinase in tracheal smooth muscle.
We investigated the role of the integrin-associated proteins focal adhesion kinase (FAK) and paxillin as mediators of… 
1999
1999
Retinoic acid increases tyrosine phosphorylation of focal adhesion kinase and paxillin in MCF-7 human breast cancer cells.
Treatment of estrogen receptor (ER)-positive MCF-7 human breast cancer cells with retinoic acid (RA) inhibited cell growth and… 
Highly Cited
1998
Highly Cited
1998
Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin.
We have previously shown that the LIM domains of paxillin operate as the focal adhesion (FA)-targeting motif of this protein. In… 
Highly Cited
1997
Highly Cited
1997
Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin.
Tyrosine phosphorylation of paxillin by the focal adhesion kinase (FAK) has been implicated as a signal transduction mechanism… 
1971
1971
Effects of S, N and P on amino acid composition of field beans (Vicia faba) and responses of the biological value of the seed protein to S-amino acid content.
In pot experiments dry matter yield of seed of Vicia faba was increased by increasing application of S at all N- and P-levels and… 
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