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pan FGFR Inhibitor PRN1371

Known as: FGFR 1-4 Inhibitor PRN1371, PRN 1371, PRN1371 
A highly specific covalent inhibitor of human fibroblast growth factor receptor types 1, 2, 3 and 4 (FGFR1-4) with potential antiangiogenic and… 
National Institutes of Health

Related topics

Related topics

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Receptor Tyrosine Kinase Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment
Aberrant activation of fibroblast growth factor receptor (FGFR) signalling contributes to progression and metastasis of many… 
2018
2018
Comprehensive genomic profiling aids in treatment of a metastatic endometrial cancer
FGFR-TACC fusions, including FGFR3-TACC3, have been identified as potential oncogenic drivers and actionable alterations in a… 
2017
2017
The Irreversible Covalent Fibroblast Growth Factor Receptor Inhibitor PRN1371 Exhibits Sustained Inhibition of FGFR after Drug Clearance
An increasing number of cancers are known to harbor mutations, translocations, or amplifications in the fibroblast growth factor… 
2016
2016
Association between insulin resistance and impairment of FGF21 signal transduction in skeletal muscles
Fibroblast growth factor (FGF) 21, was identified as a potent metabolic regulator of glucose and lipid metabolism. We… 
2016
2016
Abstract 4996: Targeting FGFR4 with monoclonal antibodies as therapeutic agents for the treatment of rhabdomyosarcoma
Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA Rhabdomyosarcoma (RMS) is the most common soft… 
2016
2016
A phase 1, multicenter, dose-escalation study of PRN1371, an irreversible covalent FGFR1-4 kinase inhibitor, in patients with advanced solid tumors, followed by expansion cohorts in patients with…
TPS2602Background: FGFR inhibition is a promising therapeutic approach in a number of solid tumors where genetic alterations of… 
2014
2014
MMP-1 and Pro-MMP-10 as Potential Urinary Pharmacodynamic Biomarkers of FGFR3-Targeted Therapy in Patients with Bladder Cancer
Purpose: The aim of this study was to identify noninvasive pharmacodynamic biomarkers of FGFR3-targeted therapies in bladder… 
2014
2014
FGFR-ERK signaling is an essential component of tissue separation.
2001
2001
Mechanisms Growth by Both Angiogenesis-dependent and-independent Factor Receptor Activity in Glioma Cells Impedes Tumor Inhibition of Fibroblast Growth Factor / Fibroblast Growth
We undertook a series of systematic studies to address the role of fibroblast growth factor/fibroblast growth factor receptor… 
1999
1999
Individualized feedback of volatile agent use reduces fresh gas flow rate, but fails to favorably affect agent choice.
BACKGROUND Cost reduction has become an important fiscal aim of many hospitals and anesthetic departments, despite its inherent… 
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