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palosuran

Known as: 1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(2-methylquinolin-4-yl)urea sulfate salt 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
The role of urotensin‐II and its receptors in sepsis‐induced lung injury under diabetic conditions
Review
2012
Review
2012
Update on potential drugs for the treatment of diabetic kidney disease.
2011
2011
Potential Clinical Implications of the Urotensin II Receptor Antagonists
Urotensin II (UII) binds to its receptor, UT, playing an important role in the heart, kidneys, pancreas, adrenal gland, and… 
Review
2010
Review
2010
Urotensin-II receptor modulators as potential drugs.
Amino acidresidues 5-10 of human U-II are contained in a disulfide-linked cyclic array, [CFWKYC], which is highly species-con… 
2009
2009
Pro-angiogenic activity of Urotensin-II on different human vascular endothelial cell populations
2009
2009
Pharmacokinetics and Pharmacodynamics of the Urotensin‐II Receptor Antagonist Palosuran in Healthy Male Subjects
Palosuran is a new potent and specific antagonist of the human urotensin II (U‐II) receptor (UT receptor). This entry‐into‐humans… 
2008
2008
Urotensin II and urotensin II-related peptide (URP) in cardiac ischemia-reperfusion injury
Review
2008
Review
2008
Urotensin II in cardiovascular regulation
Cardiovascular function is modulated by neuronal transmitters, circulating hormones, and factors that are released locally from… 
Review
2007
Review
2007
Role of urotensin II and its receptor in health and disease
Urotensin II (U-II) is currently the most potent vasoconstrictor identified. This action is brought about via activation of a Gq… 
Highly Cited
2004
Highly Cited
2004
Pharmacology of the Urotensin-II Receptor Antagonist Palosuran (ACT-058362; 1-[2-(4-Benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea Sulfate Salt): First Demonstration of a…
Urotensin-II (U-II) is a cyclic peptide now described as the most potent vasoconstrictor known. U-II binds to a specific G… 
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