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Effects of KR-32570, a new Na+/H+ exchanger inhibitor, on functional and metabolic impairments produced by global ischemia and reperfusion in the perfused rat heart.
The present study was performed to evaluate the cardioprotective effects of [5-(2-methoxy-5-chloro-5-phenyl)furan-2-ylcarbonyl]guanidine (KR-32570) on ischemia/reperfusion-induced mechanical andExpand
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Discovery of novel scaffolds for Rho kinase 2 inhibitor through TRFRET-based high throughput screening assay.
  • K. Oh, J. Mun, +6 authors B. Lee
  • Chemistry, Medicine
  • Combinatorial chemistry & high throughput…
  • 2013
Recent advances in basic and clinical studies have identified Rho kinase (ROCK) as an important target potentially implicated in a variety of cardiovascular diseases and ROCK inhibitors wereExpand
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Effects of KR-32570, a new sodium hydrogen exchanger inhibitor, on myocardial infarction and arrhythmias induced by ischemia and reperfusion.
The present study was performed to evaluate the cardioprotective effects of [5-(2-methoxy-5-chloro-5-phenyl)furan-2-ylcarbonyl]guanidine (KR-32570) in rat and dog models of coronary artery occlusionExpand
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Melanin-concentrating hormone-1 receptor antagonism and anti-obesity effects of ethanolic extract from Morus alba leaves in diet-induced obese mice.
  • K. Oh, S. Ryu, +4 authors B. Lee
  • Biology, Medicine
  • Journal of ethnopharmacology
  • 18 March 2009
ETHNOPHARMACOLOGICAL RELEVANCE In Korea, Morus alba leaves have been traditionally administered as natural therapeutic agent for the alleviating dropsy and diabetes. AIM OF THE STUDY The presentExpand
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Translational Regulation of Angiotensin Type 1a Receptor Expression and Signaling by Upstream AUGs in the 5′ Leader Sequence*
Rat angiotensin type 1a receptor (AT1aR) is regulated by four upstream AUGs present in the 5′ leader sequence (5′-LS). Disruption of all four upstream AUGs (QM) results in 2–3-fold higher levels ofExpand
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Development of a time-resolved fluorometric assay for the high throughput screening of melanin concentrating hormone receptor antagonists.
INTRODUCTION Melanin concentrating hormone is an orexigenic hypothalamic neuropeptide, which plays an important role in the complex regulation of energy balance and body weight mediated by theExpand
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Growth hormone regulation of glomerular AT1 angiotensin receptors in adult uninephrectomized male rats.
Sex differences exist in the mechanisms initiating early compensatory renal growth after unilateral nephrectomy (UNX); remnant kidney growth is growth hormone (GH) independent in adult female ratsExpand
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Translational regulation of ANG II type 1 receptors in proliferating vascular smooth muscle cells.
The current study examined angiotensin receptor (ATR) regulation in proliferating rat aortic vascular smooth muscle cells (VSMCs) in culture. Radioligand competition analysis coupled with RNaseExpand
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Identification of novel scaffolds for IκB kinase beta inhibitor via a high-throughput screening TR-FRET assay.
Control of NF-κB release through the inhibition of IκB kinase β (IKKβ) has been identified as a potential target for the treatment of inflammatory and autoimmune diseases. To screen the smallExpand
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Naphthofuroquinone derivatives: inhibition of receptor tyrosine kinases.
A series of dinaphtho[1,2-b;2',3'-d]furan-7,12-dione derivatives were synthesized and evaluated for inhibitory activities against receptor tyrosine kinases. The naphthofuroquinone compounds withExpand
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