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paclitaxel poliglumex

Known as: PPX paclitaxel cpd, polyglutamic acid-paclitaxel, polyglutamate paclitaxel 
The agent paclitaxel linked to a biodegradable, water-soluble polyglutamate polymer with antineoplastic properties. The polyglutamate residue… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
OBJECTIVES The aim of this study was to evaluate the efficacy of drug-eluting balloons (DEB) compared with paclitaxel-eluting… Expand
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Highly Cited
2010
Highly Cited
2010
A nanoparticle-conjugated cancer drug provides a novel strategy for cancer therapy. In this study, we manipulated nanodiamond (ND… Expand
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Highly Cited
2009
Highly Cited
2009
Background— In the prospective randomized Clinical Evaluation of the Xience V Everolimus Eluting Coronary Stent System in the… Expand
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Highly Cited
2008
Highly Cited
2008
Introduction: Performance status (PS) 2 patients with non-small cell lung cancer (NSCLC) experience more toxicity, lower response… Expand
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Review
2006
Review
2006
Paclitaxel is a widely used chemotherapeutic agent; however, its therapeutic index is limited by low tumor exposure and high… Expand
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Review
2005
Review
2005
  • J. Singer
  • Journal of controlled release : official journal…
  • 2005
  • Corpus ID: 23749918
Paclitaxel poliglumex (PPX) is an innovative macromolecular taxane designed to increase the therapeutic index of paclitaxel. This… Expand
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Review
2005
Review
2005
Paclitaxel poliglumex (CT-2103; XYOTAX) is an innovative macromolecular taxane designed to increase the therapeutic index of… Expand
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Highly Cited
2001
Highly Cited
2001
There are now at least seven polymer-drug conjugates that have entered phase I/II clinical trial as anticancer agents. These… Expand
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Highly Cited
1998
Highly Cited
1998
Despite an intensive search, few water-soluble paclitaxel derivatives have been shown to have a therapeutic index superior to… Expand
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Highly Cited
1997
Highly Cited
1997
The purpose of this work was to characterize the solid-state properties of anhydrous paclitaxel and paclitaxel dihydrate… Expand
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