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paclitaxel poliglumex

Known as: PPX paclitaxel cpd, polyglutamic acid-paclitaxel, polyglutamate paclitaxel 
The agent paclitaxel linked to a biodegradable, water-soluble polyglutamate polymer with antineoplastic properties. The polyglutamate residue… 
National Institutes of Health

Related topics

Related topics

7 relations

Narrower (2)

CT-2103XYOTAX
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Broader (3)

PaclitaxelPolyglutamic AcidTaxol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
SPARC-Independent Delivery of Nab-Paclitaxel without Depleting Tumor Stroma in Patient-Derived Pancreatic Cancer Xenografts
The study goal was to examine the relationship between nab-paclitaxel delivery and SPARC (secreted protein acidic and rich in… 
2014
2014
A Cell-Based Pharmacokinetics Assay for Evaluating Tubulin-Binding Drugs
Increasing evidence reveals that traditional pharmacokinetics parameters based on plasma drug concentrations are insufficient to… 
2010
2010
Evaluation of the effects of everolimus‐eluting and paclitaxel‐eluting stents on target lesions with jailed side branches: 2‐year results from the SPIRIT III randomized trial
Objective: To evaluate whether an everolimus‐eluting stent (EES) with thinner stent struts and polymer results in less… 
Highly Cited
2009
Highly Cited
2009
Long-Term outcome of drug-eluting stents compared with bare metal stents in ST-segment elevation myocardial infarction: results of the paclitaxel- or sirolimus-eluting stent versus bare metal stent…
BACKGROUND Drug-eluting stents may offer benefits in terms of repeat revascularization that may be counterbalanced by a potential… 
2009
2009
Neoadjuvant paclitaxel poliglumex, cisplatin, and radiation for esophageal cancer: A phase II trial.
e15542 Background: Paclitaxel poliglumex (PPX) is a drug conjugate that links paclitaxel to poly-L-glutamic acid thereby… 
Review
2004
Review
2004
Chemoradiotherapy for uterine cancer: current status and perspectives
The conventional local treatment methods (surgery and radiation) for cervical cancer have reached a plateau in terms of survival… 
2004
2004
Phase I study of CT-2106 (polyglutamate camptothecin) in patients with advanced malignancies.
3127 Background: CT-2106, a camptothecin (CPT) conjugate, is a new generation of topoisomerase I inhibitors designed to deliver… 
Review
2000
Review
2000
Hepatic chemoembolization: clinical and experimental correlation.
Chemoembolization has become the preferred treatment for patients with inoperable, hypervascular hepatic malignancies in the Far… 
Review
1990
Review
1990
In vivo methotrexate kinetics and metabolism in human hematopoietic cells. Clinical significance of methotrexate concentrations in erythrocytes.
The author has performed in vivo investigations of the methotrexate (MTX) accumulation, kinetics and polyglutamate metabolism in… 
Highly Cited
1977
Highly Cited
1977
Identification of folate binding proteins in rat liver.
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