paclitaxel poliglumex

Known as: PPX paclitaxel cpd, polyglutamic acid-paclitaxel, polyglutamate paclitaxel 
The agent paclitaxel linked to a biodegradable, water-soluble polyglutamate polymer with antineoplastic properties. The polyglutamate residue… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
OBJECTIVES The aim of this study was to evaluate the efficacy of drug-eluting balloons (DEB) compared with paclitaxel-eluting… (More)
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Highly Cited
2009
Highly Cited
2009
OBJECTIVES We sought to assess changes in antirestenotic efficacy of drug-eluting stents (DES) by restudying subjects at 2 time… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND In the prospective randomized Clinical Evaluation of the Xience V Everolimus Eluting Coronary Stent System in the… (More)
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Highly Cited
2008
Highly Cited
2008
INTRODUCTION Performance status (PS) 2 patients with non-small cell lung cancer (NSCLC) experience more toxicity, lower response… (More)
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Review
2006
Review
2006
Paclitaxel is a widely used chemotherapeutic agent; however, its therapeutic index is limited by low tumor exposure and high… (More)
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2006
2006
Background The efficacy and tolerability of paclitaxel is limited by its low solubility, high systemic exposure, and a lack of… (More)
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2006
2006
OBJECTIVES To determine the maximal tolerated dose (MTD) and dose limiting toxicities of poly(l-glutamic acid)-paclitaxel (PPX… (More)
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Review
2005
Review
2005
Paclitaxel poliglumex (PPX) is an innovative macromolecular taxane designed to increase the therapeutic index of paclitaxel. This… (More)
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Review
2005
Review
2005
Paclitaxel poliglumex (CT-2103; XYOTAX) is an innovative macromolecular taxane designed to increase the therapeutic index of… (More)
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Highly Cited
1998
Highly Cited
1998
Despite an intensive search, few water-soluble paclitaxel derivatives have been shown to have a therapeutic index superior to… (More)
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