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p53-HDM2 Interaction Inhibitor MI-773

Known as: MI-773, p53-MDM2 Interaction Inhibitor MI-773 
An orally available spiro-oxindole HDM2 (human double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, the p53… 
National Institutes of Health

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SAR405838

Papers overview

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2019
2019
Abstract C060: Broad spectrum activity of the MDM2 inhibitor MI-773 in hematologic and solid cancer cell linesin-vitroand determination of predictive biomarkers
2017
2017
A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53
Protein–protein interactions (PPIs) are fundamental to the growth and survival of cells and serve as excellent targets to develop… 
2014
2014
Abstract 5451: Profiling inhibitors of MDM2:p53 and MDMX:p53 in relation to MDMX protein levels
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Pharmacological antagonism of the interaction between MDM2… 
2013
2013
Effective Screening Strategy Using Ensembled Pharmacophore Models Combined with Cascade Docking: Application to p53-MDM2 Interaction Inhibitors
Protein-protein interactions (PPIs) play a crucial role in cellular function and form the backbone of almost all biochemical… 
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