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p27 Enzyme Inhibitor

Known as: P27 
National Institutes of Health

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2 relations
P27 Ag:PrThr:Pt:Tiss:Ord:Immune stainp27 Cell Cycle Protein

Papers overview

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Highly Cited
2015
Highly Cited
2015
The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27Kip1
Growing evidence suggests that YAP/TAZ are mediators of the Hippo pathway and promote breast cancer. However, the roles of YAP… 
2015
2015
Abstract P5-18-01: TransHERA: The cell cycle regulator p27 predicts benefit from trastuzumab treatment in HER2-positive early breast cancer patients treated within the HERA trial
Purpose: Predictive biomarkers may help predicting adjuvant trastuzumab response and thus optimize the treatment of patients with… 
2014
2014
SIRT 1 Inactivation Evokes Antitumor Activities in NSCLC through the Tumor Suppressor p 27
P27 (CDKN1B) regulates cellular proliferation and senescence, and p27 deficiency in cancer is strongly correlated with poor… 
2007
2007
Glycogen Synthase Kinase - 3 Phosphorylates and Regulates the Stability of p27kip1 Protein
p27 Kip1 is a critical regulator of the eukaryotic cell cycle. It acts as a check point proteinand regulates cell cycle… 
2007
2007
Hepatitis B Virus PreS 2 Mutant Surface Antigen Induces Degradation of Cyclin-Dependent Kinase Inhibitor p 27 Kip 1 through c-Jun Activation Domain-Binding Protein 1
The hepatitis B virus (HBV) large surface antigen (LHBS) mutant with deletion at the pre-S2 region accumulates in endoplasmic… 
2007
2007
No evidence for amplification of V617F JAK2 in myeloproliferative disorders
Acquired uniparental disomy following mitotic recombination results in homozygosity for the V617F JAK2 mutation in a proportion… 
Highly Cited
2003
Highly Cited
2003
p27Kip1 Inhibition of GRB2-SOS Formation Can Regulate Ras Activation
ABSTRACT p27Kip1 (p27) is often inappropriately downregulated in aggressive human cancers. Although p27 can inhibit cyclin… 
2003
2003
Expression of p27(Kip1) and c-Jun activation binding protein 1 are inversely correlated in systemic anaplastic large cell lymphoma.
PURPOSE p27(Kip1)(p27) is a universal cyclin-dependent kinase inhibitor that inhibits cell cycle transition from G(1) to S phase… 
2003
2003
Regulation of p27 in the process of neuroblastoma N2A differentiation
Neuronal differentiation implies morphological and biochemical changes to generate a specialized neuron. N2A neuroblastoma cells… 
Highly Cited
1998
Highly Cited
1998
Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal…
It has been suggested that overexpression of the Bcl-2 oncoprotein in human cancer cells contributes to their resistance to… 
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