No evidence for amplification of V617F JAK2 in myeloproliferative disorders

@article{Jones2007NoEF,
  title={No evidence for amplification of V617F JAK2 in myeloproliferative disorders},
  author={Allison V Jones and David Bunyan and Nicholas C. P. Cross},
  journal={Leukemia},
  year={2007},
  volume={21},
  pages={2561-2563}
}
normally found in Phþ ALL, CML associated p210 ABL by virtue of its unique Dbl/Plecstrin-homology domain, can bind to small GTPases of the Rho family both in vitro and in vivo. This in turn gives rise to Rho activation, which might be responsible for promoting cellular motility. Taken together, it need to be substantiated whether or not these events do… CONTINUE READING