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orotate

 
National Institutes of Health

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Highly Cited
2006
Highly Cited
2006
Background: Teriflunomide, a dihydro-orotate dehydrogenase inhibitor, has immunomodulatory effects, including the ability to… Expand
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Highly Cited
2005
Highly Cited
2005
The purine analogue, allopurinol, has been in clinical use for more than 30 years as an inhibitor of xanthine oxidase (XO) in the… Expand
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Highly Cited
2003
Highly Cited
2003
Activation of 5-fluorouracil into its nucleotides requires phosphorylation by three pathways involving orotate phosphoribosyl… Expand
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Highly Cited
2002
Highly Cited
2002
The complete genomic sequence of an intracellular bacterial pathogen, Mycoplasma penetrans HF-2 strain, was determined. The HF-2… Expand
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Highly Cited
2002
Highly Cited
2002
Purine and pyrimidine nucleotides are major energy carriers, subunits of nucleic acids and precursors for the synthesis of… Expand
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Highly Cited
1998
Highly Cited
1998
Leflunomide is currently in phase-III clinical trials for the treatment of rheumatoid arthritis. In this study, we have focused… Expand
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Highly Cited
1979
Highly Cited
1979
The conversion of dihydroorotate to orotate, one of the key reactions in the de novo pyrimidine biosynthetic pathway, has been… Expand
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Highly Cited
1974
Highly Cited
1974
Abstract 1. d-Galactosamine induces a selective deficiency of UTP without reducing the pools of ATP, GTP, or CTP. This has been… Expand
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Highly Cited
1973
Highly Cited
1973
Adenosine at low concentration is toxic to mammalian cells in culture. This may escape notice because some sera (such as calf or… Expand
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Highly Cited
1970
Highly Cited
1970
The effects of d-galactosamine, d-glucosamine, and 2-deoxy-d-galactose on rat liver uracil nucleotides were studied in vivo… Expand
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