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oleandrin

Known as: (3 beta,16 beta)-16-(acetyloxy)-3-((2,6-dideoxy-3-O-methyl-L-arabino-hexopyranosyl)oxy)-14-hydroxy card-20(22)-enolide 
A lipid soluble cardiac glycoside with potential antineoplastic activity. Upon administration, oleandrin specifically binds to and inhibits the… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Cardiac glycosides such as oleandrin are known to inhibit the Na,K-ATPase pump, resulting in a consequent increase in calcium… Expand
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Review
2007
Review
2007
Cardiotonic steroids (CTS), long used to treat heart failure, are endogenously produced in mammals. Among them are the… Expand
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Highly Cited
2007
Highly Cited
2007
Lipid-soluble cardiac glycosides such as bufalin, oleandrin, and digitoxin have been suggested as potent agents that might be… Expand
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2007
2007
Common practice to evaluate the efficacy of any compound as drug is done in cell-based in vitro system followed by in vivo murine… Expand
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2006
2006
While certain cardiac glycoside compounds such as oleandrin, bufalin and digitoxin are known to be associated with potent… Expand
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2003
2003
Ceramide (N-acetyl-D-sphingosine), a second messenger for cell signaling induces transcription factors, like nuclear factor-kappa… Expand
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Highly Cited
2001
Highly Cited
2001
Anvirzel is an extract of Nerium oleander currently undergoing Phase I clinical evaluation as a potential treatment for cancer… Expand
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Highly Cited
2000
Highly Cited
2000
Agents that can suppress the activation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) may be able to block… Expand
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Highly Cited
2000
Highly Cited
2000
Cardiac glycosides are used clinically to increase contractile force in patients with cardiac disorders. Their mechanism of… Expand
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1996
1996
Ingestion of oleander plant, containing the cardiac glycoside oleandrin, has been reported to induce fatal poisonings… Expand
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