nucleoside inhibitor

 
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
BACKGROUND & AIMS We evaluated an all-oral regimen comprising the nucleotide polymerase inhibitor sofosbuvir (SOF) with the NS5A… (More)
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Highly Cited
2009
Highly Cited
2009
Dengue virus (DENV), a mosquito-borne flavivirus, is a major public health threat. The virus poses risk to 2.5 billion people… (More)
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Highly Cited
2009
Highly Cited
2009
Entecavir is a potent nucleoside inhibitor of the hepatitis B virus (HBV) polymerase with a high antiviral efficacy and a high… (More)
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2000
2000
Abacavir (1592U89) is a nucleoside inhibitor of human immunodeficiency virus (HIV) type 1 reverse transcriptase (RT). Resistance… (More)
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Highly Cited
1999
Highly Cited
1999
Nevirapine (NVP), a non-nucleoside inhibitor of HIV-1 reverse transcriptase, is concomitantly administered to patients with a… (More)
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Highly Cited
1999
Highly Cited
1999
In order to study the inferences of structure for mechanism, the collective motions of the retroviral reverse transcriptase HIV-1… (More)
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1999
1999
Efavirenz (EFV, Sustiva, Stocrin, DMP-266, L-743,726) is a potent and selective non-nucleoside inhibitor of HIV-1 reverse… (More)
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Highly Cited
1998
Highly Cited
1998
HIV-1 replication is inhibited by the incorporation of chain-terminating nucleotides at the 3' end of the growing DNA chain. Here… (More)
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1998
1998
Substrate and product specificity studies were used to develop inhibitors of the cytosolic 5'-nucleotidase I (c-N-I) from… (More)
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Highly Cited
1995
Highly Cited
1995
The structure of unliganded HIV-1 reverse transcriptase has been determined at 2.35 Å resolution and refined to an R-factor of 0… (More)
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