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noroxycodone

 
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
BACKGROUND AND PURPOSE There is high interindividual variability in the activity of drug-metabolizing enzymes catalysing the… Expand
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2008
2008
A sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND In vitro experiments suggest that circulating metabolites of oxycodone are opioid receptor agonists. Clinical and… Expand
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Highly Cited
2004
Highly Cited
2004
Oxycodone undergoes N-demethylation to noroxycodone and O-demethylation to oxymorphone. The cytochrome P450 (P450) isoforms… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Oxycodone is metabolized in the liver by means of O-demethylation to form oxymorphone in a reaction catalyzed by the… Expand
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Highly Cited
1996
Highly Cited
1996
STUDY OBJECTIVE To determine the pharmacokinetics of oxycodone and the excretion of oxycodone and its metabolites noroxycodone… Expand
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Highly Cited
1996
Highly Cited
1996
Plasma concentrations of oxycodone, oxymorphone, and noroxycodone were determined after administration of 20 mg oral controlled… Expand
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1994
1994
The antinociceptive activity of noroxycodone (NOR) was determined and its potency compared with that of oxycodone (OXY) and… Expand
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Highly Cited
1992
Highly Cited
1992
1. The pharmacokinetics and metabolism of oxycodone were studied in nine healthy young volunteers in a cross-over study. Each… Expand
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Highly Cited
1991
Highly Cited
1991
Oxycodone chloride (0.07 mg kg-1) was given by intravenous bolus to nine young adult surgical patients on the first postoperative… Expand
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