noroxycodone

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2018
0519792018

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2011
2011
The aim of this study was to evaluate the plasma dispositions of oxycodone and its demethylates and dose escalation based on… (More)
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2009
2009
BACKGROUND Oxycodone is a mu-opioid receptor agonist that is metabolized mainly in the liver by cytochrome P450 3A and 2D6… (More)
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2008
2008
A sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND In vitro experiments suggest that circulating metabolites of oxycodone are opioid receptor agonists. Clinical and… (More)
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Highly Cited
2004
Highly Cited
2004
Oxycodone undergoes N-demethylation to noroxycodone and O-demethylation to oxymorphone. The cytochrome P450 (P450) isoforms… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Oxycodone is metabolized in the liver by means of O-demethylation to form oxymorphone in a reaction catalyzed by the… (More)
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1996
1996
STUDY OBJECTIVE To determine the pharmacokinetics of oxycodone and the excretion of oxycodone and its metabolites noroxycodone… (More)
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1994
1994
The antinociceptive activity of noroxycodone (NOR) was determined and its potency compared with that of oxycodone (OXY) and… (More)
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Highly Cited
1992
Highly Cited
1992
1. The pharmacokinetics and metabolism of oxycodone were studied in nine healthy young volunteers in a cross-over study. Each… (More)
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1979
1979
An electron-capture GLC method is described for oxycodone and its major metabolite, noroxycodone, in plasma and urine. The method… (More)
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