nitrosonifedipine
National Institutes of Health
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New applications of approved clinically used drugs are being discovered. Drug repositioning is a proposed strategy for developing…
Objective: Nitrosonifedipine (NO-NIF) is photolytic metabolite of nifedipine, an anti-hypertensive drug. We have revealed that NO…
INTRODUCTION: Ischemic flap necrosis is often occurred by insufficient blood supply, which prolongs the treatment period and…
Diabetic nephropathy (DN) is the major cause of end-stage renal failure. Oxidative stress is implicated in the pathogenesis of DN…
Nifedipine is unstable under light and decomposes to a stable nitroso analog, nitrosonifedipine (NO-NIF). The ability of NO-NIF…
Diabetic nephropathy (DN) is a major microvascular complication of diabetes involving oxidative stress and endothelial damage…
Recently, increasing evidence suggests that the antihypertensive drug nifedipine acts as a protective agent for endothelial cells…