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negative regulation of histone H3-K27 acetylation

Known as: inhibition of histone H3 acetylation at K27, downregulation of histone H3K27 acetylation, down regulation of histone H3K27 acetylation 
Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 acetylation. [GOC:BHF, GOC:TermGenie]
National Institutes of Health

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2 relations

Broader (1)

biological control
histone H3-K27 acetylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
CDYL promotes the chemoresistance of small cell lung cancer by regulating H3K27 trimethylation at the CDKN1C promoter
Rationale: Chemoresistance frequently occurs in patients with small cell lung cancer (SCLC) and leads to a dismal prognosis… 
Review
2016
Review
2016
Polycomb repressive complex’s evolutionary conserved function: the role of EZH2 status and cellular background
When assembled in multiprotein polycomb repressive complexes (PRCs), highly evolutionary conserved polycomb group (PcG) proteins… 
2016
2016
A double-negative feedback loop between EZH2 and miR-26a regulates tumor cell growth in hepatocellular carcinoma.
Accumulating evidence demonstrates the important roles of microRNAs (miRNAs) in tumor development and progression. miR-26a has… 
Highly Cited
2015
Highly Cited
2015
The Histone Demethylase UTX Promotes Brown Adipocyte Thermogenic Program Via Coordinated Regulation of H3K27 Demethylation and Acetylation*
Background: Brown fat functions to dissipate energy through adaptive thermogenesis. Results: The histone demethylase UTX… 
Highly Cited
2013
Highly Cited
2013
The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis
Histone chaperones affect chromatin structure and gene expression through interaction with histones and RNA polymerase II (PolII… 
Highly Cited
2013
Highly Cited
2013
Histone H2A Ubiquitination Inhibits the Enzymatic Activity of H3 Lysine 36 Methyltransferases*
Background: H3K36 methylation antagonizes Polycomb function, but it is not clear whether the reverse is true. Results: H3K36… 
Highly Cited
2011
Highly Cited
2011
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
Highly Cited
2011
Highly Cited
2011
Control of Flowering and Cell Fate by LIF2, an RNA Binding Partner of the Polycomb Complex Component LHP1
Polycomb Repressive Complexes (PRC) modulate the epigenetic status of key cell fate and developmental regulators in eukaryotes… 
Highly Cited
2007
Highly Cited
2007
CTCF Is the Master Organizer of Domain-Wide Allele-Specific Chromatin at the H19/Igf2 Imprinted Region
ABSTRACT A paternally methylated imprinting control region (ICR) directs allele-specific expression of the imprinted H19 and Igf2… 
Highly Cited
2006
Highly Cited
2006
Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells
Human enhancer of zeste 2 (EZH2) protein belongs to the multiprotein polycomb repressive complex 2, which also includes… 
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