The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis.

  title={The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis.},
  author={Aibing Wang and Hossein Zare and Kambiz Mousavi and Chaochen Wang and Cara E Moravec and Howard I Sirotkin and Kai Ge and Gustavo Gutierrez-Cruz and Vittorio Sartorelli},
  journal={The EMBO journal},
  volume={32 8},
Histone chaperones affect chromatin structure and gene expression through interaction with histones and RNA polymerase II (PolII). Here, we report that the histone chaperone Spt6 counteracts H3K27me3, an epigenetic mark deposited by the Polycomb Repressive Complex 2 (PRC2) and associated with transcriptional repression. By regulating proper engagement and function of the H3K27 demethylase KDM6A (UTX), Spt6 effectively promotes H3K27 demethylation, muscle gene expression, and cell… CONTINUE READING


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UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.

Proceedings of the National Academy of Sciences of the United States of America • 2012
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