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necitumumab

Known as: Immunoglobulin G1, Anti-(Human Epidermal Growth Factor Receptor (Receptor Tyrosine-Protein Kinase ErbB-1, EC 2.7.10.1)); Human Monoclonal IMC-11F8 Gamma1 Heavy Chain (224-214')-Disulfide with Human Monoclonal IMC-11F8 Kappa Light Chain, Dimer (230- 230'':233-233'')-Bisdisulfide 
A fully human IgG1 monoclonal antibody directed against the epidermal growth factor receptor (EGFR) with potential antineoplastic activity… 
National Institutes of Health

Related topics

Related topics

5 relations
50 ML necitumumab 16 MG/ML Injection [Portrazza]HER1 Antagonists [MoA]antigen binding

Narrower (1)

IMC-11F8

Broader (1)

Monoclonal Antibodies

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Spotlight on necitumumab in the treatment of non-small-cell lung carcinoma
The treatment options for metastatic non-small-cell lung cancer (NSCLC) have expanded dramatically in the last 10 years with the… 
2017
2017
EGFR immunohistochemistry as biomarker for antibody-based therapy of squamous NSCLC - Experience from the first ring trial of the German Quality Assurance Initiative for Pathology (QuIP®).
Review
2016
Review
2016
The impending financial healthcare burden and ethical dilemma of systemic therapy in metastatic cancer
Metastatic cancer remains a devastating disease that threatens to disrupt entire family structures creating economic and… 
2016
2016
Necitumumab for first-line treatment of advanced, squamous, non-small-cell lung cancer: a relevant step forward?
Squamous-cell lung carcinoma accounts for approximately 30-40% of the non-small-cell lung cancer (NSCLC) cases in our setting (1… 
Review
2016
Review
2016
Drugs That Act on the Immune System: Cytokines and Monoclonal Antibodies
Review
2015
Review
2015
Necitumumab for non-small cell lung cancer
Introduction: Targeting the EGFR pathway is a rational approach to treat patients with advanced NSCLC. Necitumumab, a second… 
Review
2015
Review
2015
Epidermal growth factor receptor-directed monoclonal antibodies in nonsmall cell lung cancer: an update
Purpose of review The epidermal growth factor receptor (EGFR) is overexpressed in many nonsmall cell lung cancers (NSCLCs… 
2015
2015
Necitumumab for the treatment of stage IV metastatic squamous non-small-cell lung cancer
Over the past two decades, progress in the treatment of patients with metastatic squamous non-small-cell lung cancer has been… 
Review
2014
Review
2014
Treatment Paradigms for Patients with Metastatic Non-Small Cell Lung Cancer, Squamous Lung Cancer: First, Second, and Third-Line
Historically, the treatment algorithm applied to non-small cell lung cancer (NSCLC) was the same for all histologic subtypes… 
Review
2014
Review
2014
Promising Targets and Current Clinical Trials in Metastatic Squamous Cell Lung Cancer
Squamous cancer of the lung (SQCC), although no longer the premier variant of non-small cell lung cancer, continues to impose a… 
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