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necdin

Known as: Necdin Homolog (Mouse), Necdin (Mouse) Homolog, Prader-Willi Syndrome Chromosome Region 
Necdin (321 aa, ~36 kDa) is encoded by the human NDN gene. This protein plays a role in suppression of cell growth in postmitotic neurons.
National Institutes of Health

Related topics

Related topics

7 relations
Cell Cycle ControlGenes, RegulatorGenes, cdcNDN gene

Broader (2)

Nerve Tissue ProteinsNuclear Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Necdin Promotes GABAergic Neuron Differentiation in Cooperation with Dlx Homeodomain Proteins
Necdin, a member of the MAGE (melanoma antigen) protein family, is expressed predominantly in terminally differentiated neurons… 
Highly Cited
2005
Highly Cited
2005
Essential role for the Prader-Willi syndrome protein necdin in axonal outgrowth.
Necdin and Magel2 are related proteins inactivated in Prader-Willi syndrome (PWS), a sporadic chromosomal deletion disorder. We… 
Highly Cited
2004
Highly Cited
2004
Necdin-related MAGE Proteins Differentially Interact with the E2F1 Transcription Factor and the p75 Neurotrophin Receptor*
Necdin is a growth suppressor expressed predominantly in postmitotic neurons and implicated in their terminal differentiation… 
Highly Cited
2003
Highly Cited
2003
Absence of Ndn, Encoding the Prader-Willi Syndrome-Deleted Gene necdin, Results in Congenital Deficiency of Central Respiratory Drive in Neonatal Mice
necdin (Ndn) is one of a cluster of genes deleted in the neurodevelopmental disorder Prader-Willi syndrome. necdin is upregulated… 
Review
2002
Review
2002
The MAGE proteins: Emerging roles in cell cycle progression, apoptosis, and neurogenetic disease
Since the identification of the first MAGE gene in 1991, the MAGE family has expanded dramatically, and over 25 MAGE genes have… 
Review
2000
Review
2000
Cell cycle regulators in neural stem cells and postmitotic neurons
Highly Cited
1999
Highly Cited
1999
Physical and Functional Interactions of Neuronal Growth Suppressor Necdin with p53*
Necdin is expressed in virtually all postmitotic neurons, and ectopic expression of this protein suppresses cell proliferation… 
Highly Cited
1998
Highly Cited
1998
Necdin, A Postmitotic Neuron-specific Growth Suppressor, Interacts with Viral Transforming Proteins and Cellular Transcription Factor E2F1*
Necdin is a nuclear protein expressed in virtually all postmitotic neurons, and ectopic expression of this protein strongly… 
Highly Cited
1996
Highly Cited
1996
Structure and Expression of the Mouse Necdin Gene
Necdin is a 325 amino acid residue protein encoded by a cDNA clone isolated from neurally differentiated embryonal carcinoma… 
Highly Cited
1995
Highly Cited
1995
Arrest of cell growth by necdin, a nuclear protein expressed in postmitotic neurons.
Necdin is a 325 amino acid residue protein localized to the nuclei of postmitotic neurons, which withdraw permanently from the… 
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