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Social network websites, such as Facebook, YouTube, Lastfm etc, have become a popular platform for users to connect with each other and share content or opinions. They provide rich information for us to study the influence of user's social circle in their decision process. In this paper, we are interested in examining the effectiveness of social network(More)
Inflammatory cytokines such as interleukin-17 (IL-17) promote inflammatory autoimmune diseases. Although several microRNAs (miRNAs) have been shown to regulate autoimmune pathogenesis by affecting lymphocyte development and function, the role of miRNAs in resident cells present in inflammatory lesions remains unclear. Here we show that miR-23b is(More)
The neural circuitry that constrains visual acuity in the CNS has not been experimentally identified. We show here that zebrafish blumenkohl (blu) mutants are impaired in resolving rapid movements and fine spatial detail. The blu gene encodes a vesicular glutamate transporter expressed by retinal ganglion cells. Mutant retinotectal synapses release less(More)
Many multivariate time series data in practical applications, such as health care, geoscience, and biology, are characterized by a variety of missing values. It has been noted that the missing patterns and values are often correlated with the target labels, a.k.a., missingness is informative, and there is significant interest to explore methods which model(More)
A proportionality or balance between coactivated excitatory and inhibitory inputs is often observed for individual cortical neurons and is proposed to be important for their functions. This feature of neural circuits may arise from coordinated modulation of excitatory and inhibitory synaptic inputs, a mechanism that remains unknown. Here, in vivo whole-cell(More)
Tumblr, as one of the most popular microblogging platforms, has gained momentum recently. It is reported to have 166.4 millions of users and 73.4 billions of posts by January 2014. While many articles about Tumblr have been published in major press, there is not much scholar work so far. In this paper, we provide some pioneer analysis on Tumblr from a(More)
In this MRI study, we aimed to provide new in vivo structural markers of asymmetry in motor and language networks in a population of healthy preterm neonates scanned at term equivalent age. Using diffusion tensor imaging and probabilistic tractography, we showed that, besides volume and microstructural asymmetries in the parieto-temporal part of the(More)
A DNA nanostructure consisting of four four-arm junctions oriented with a square aspect ratio was designed and constructed. Programmable self-assembly of 4 x 4 tiles resulted in two distinct lattice morphologies: uniform-width nanoribbons and two-dimensional nanogrids, which both display periodic square cavities. Periodic protein arrays were achieved by(More)
Interleukin 17 (IL-17) plays critical roles in the pathogenesis of various autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE). How the signals triggered by this powerful inflammatory cytokine are controlled to avoid abnormal inflammatory responses is not well understood. In this study, we report that TRAF3 is a receptor proximal(More)