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nebicapone

Known as: 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanone 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Acetophenones

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
In‐vivo evaluation of prolonged release bilayer tablets of anti‐Parkinson drugs in Göttingen minipigs
Objectives  Patients with Parkinson's disease can benefit from controlled released levodopa dosage forms since there is a clear… Expand
2010
2010
A Double‐Blind, Randomized, Placebo and Active‐Controlled Study of Nebicapone for the Treatment of Motor Fluctuations in Parkinson's Disease
To determine the efficacy, safety and tolerability of nebicapone, a new catechol‐O‐methyltransferase inhibitor for the treatment… Expand
Review
2010
Review
2010
Toxicology and safety of COMT inhibitors.
  • K. Haasio
  • International review of neurobiology
  • 2010
    • Corpus ID: 21860089
The development of catechol-O-methyltransferase (COMT) inhibitors for the adjunct treatment to levodopa and aromatic L-amino acid… Expand
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Review
2010
Review
2010
Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson's disease.
  • S. Kaakkola
  • International review of neurobiology
  • 2010
    • Corpus ID: 883048
Entacapone and tolcapone are reversible COMT inhibitors which have been approved for clinical use in patients with Parkinson… Expand
2010
2010
Chronopharmacology of nebicapone, a new catechol-O-methyltransferase inhibitor
Abstract Objective: To investigate the chronopharmacology of nebicapone, a new catechol-O-methyltransferase (COMT) inhibitor… Expand
2009
2009
Species differences in pharmacokinetic and pharmacodynamic properties of nebicapone.
The present study was designed to characterize pharmacodynamic and pharmacokinetic properties of nebicapone in rats and mice… Expand
2009
2009
Pharmacokinetic-pharmacodynamic interaction between nebicapone and controlled-release levodopa/benserazide: a single-center, Phase I, double-blind, randomized, placebo-controlled, four-way crossover…
BACKGROUND Nebicapone is a reversible catechol-O-methyltransferase (COMT) inhibitor. Coadministration of a COMT inhibitor with… Expand
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2008
2008
Effects of Nebicapone on Levodopa Pharmacokinetics, Catechol-O-methyltransferase Activity, and Motor Fluctuations in Patients with Parkinson Disease
Objective: To investigate the effects of nebicapone, a new catechol-O-methyltransferase (COMT) inhibitor, on levodopa… Expand
2006
2006
Human Metabolism of Nebicapone (BIA 3-202), a Novel Catechol-O-Methyltransferase Inhibitor: Characterization of in Vitro Glucuronidation
Nebicapone (BIA 3-202; 1-[3,4-dihydroxy-5-nitrophenyl]-2-phenylethanone), a novel catechol-O-methyltransferase inhibitor, is… Expand
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2002
2002
Chemical synthesis and characterization of conjugates of a novel catechol-O-methyltransferase inhibitor.
BIA 3-202, 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanone 3, is a novel, reversible, and tight-binding peripheral inhibitor of… Expand
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