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napsagatran

Known as: N-(N4-(((S)-1-amidino-3-piperidinyl)methyl)-N2-(2-naphthalenesulfonyl)-L-asparaginyl)-N-cyclopropylglycine 
National Institutes of Health

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2 relations

Broader (2)

NaphthalenesPiperidines

Papers overview

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Review
2008
Review
2008
Overview of Direct Thrombin Inhibitors in Clinical Practice
Novel anticoagulants have been developed that specifically target activated coagulation factor X or thrombin. This article… 
Review
2002
Review
2002
[Management of heparin-induced thrombocytopenia].
Immune-mediated (type II) heparin-induced thrombocytopenia (HIT) is a common and potentially serious averse effect of heparin… 
Review
2001
Review
2001
Pharmacokinetics of an emerging new class of anticoagulant/antithrombotic drugs
Abstract. Small-molecule direct thrombin inhibitors represent a new class of anticoagulants and are emerging as antithrombotic… 
2001
2001
The effect of warfarin on the pharmacokinetics and pharmacodynamics of napsagatran in healthy male volunteers
Abstract. Objective: The effect of oral warfarin on the pharmacokinetics and pharmacodynamics of the synthetic direct thrombin… 
1999
1999
Differential Inhibition of Thrombin Activity and Thrombin Generation by a Synthetic Direct Thrombin Inhibitor (Napsagatran, Ro 46-6240) and Unfractionated Heparin in Patients with Deep Vein…
Summary Background: Direct thrombin inhibitors belong to a new class of antithrombotic drugs whose effects on blood coagulation… 
1997
1997
An Exploratory Trial of Two Dosages of a Novel Synthetic Thrombin Inhibitor (Napsagatran, Ro 46-6240) Compared with Unfractionated Heparin for Treatment of Proximal Deep-vein Thrombosis
Summary One hundred and ten patients with acute proximal deep-vein thrombosis were randomized in a sequential dose-finding design… 
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