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naftifine

Known as: 1-Naphthalenemethanamine, N-methyl-N-(3-phenyl-2-propenyl)-, (E)-, Naftifina, naftifine [Chemical/Ingredient] 
A topical, synthetic allylamine derivate similar to terbinafine with broad-spectrum antifungal activity. Naftifine can be fungicidal or fungistatic… 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (2)

AllylamineAntifungal Agents
HypersensitivityMycosesNaftifine hydrochloride 0.02 MG/MG Topical Gel [Naftin]Naftifine hydrochloride 10 MG/ML Topical Cream [Naftin]

Narrower (2)

Naftifine hydrochlorideNaftin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
In-vitro Activity of 10 Antifungal Agents against 320 Dermatophyte Strains Using Microdilution Method in Tehran
Dermatophyte fungi are the etiologic agents of skin infections commonly referred to as ringworm. These infections are not… 
Review
2012
Review
2012
A Review of its Pharmacological Properties and Therapeutic Potential in the Treatment of Onychomycosis and Other Superficial Fungal Infections
Various sections of the manuscript reviewed by: Y.M. Clayton, Institute of Dermatology, St Thomas' Hospital, London, England; A… 
Highly Cited
2011
Highly Cited
2011
Substrate-directable Heck reactions with arenediazonium salts. The regio- and stereoselective arylation of allylamine derivatives and applications in the synthesis of naftifine and abamines.
The palladium-catalyzed, substrate-directable Heck-Matsuda reaction of allylamine derivatives with arenediazonium salts is… 
Highly Cited
1997
Highly Cited
1997
In‐vitro Permeability of the Human Nail and of a Keratin Membrane from Bovine Hooves: Prediction of the Penetration Rate of Antimycotics through the Nail Plate and their Efficacy
In contrast to the partition coefficient octanol/water the molecular size of penetrating drugs has a noticeable influence on the… 
Highly Cited
1993
Highly Cited
1993
IN VITRO SUSCEPTIBILITY OF DERMATOPHYTES TO ANTIFUNGAL DRUGS: A COMPARISON OF TWO METHODS
Background. There is an evidence that some fungal strains are resistant to certain antimycotic drugs with resulting therapeutic… 
Review
1990
Review
1990
Pharmacology of the allylamines.
Highly Cited
1986
Highly Cited
1986
Synthesis and structure-activity relationships of naftifine-related allylamine antimycotics.
Naftifine (1) is the first representative of the new antifungal allylamine derivatives. Its biological activity is strictly bound… 
Highly Cited
1984
Highly Cited
1984
Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase.
A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical… 
Highly Cited
1981
Highly Cited
1981
In vivo antimycotic activity of naftifine
Naftifine, a new antifungal agent belonging chemically to the allylamines, was tested for its in vivo activity after topical… 
Highly Cited
1981
Highly Cited
1981
In vitro activity of naftifine, a new antifungal agent
Naftifine exhibits an interesting in vitro spectrum of activity against dermatophytes (38 strains; minimal inhibitory… 
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