myofibroblast differentiation

Known as: myofibroblast cell differentiation 
The process in which an undifferentiated cell acquires the features of a myofibroblast cell. [CL:0000186, GOC:nhn]
National Institutes of Health

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3 relations
negative regulation of myofibroblast differentiationpositive regulation of myofibroblast differentiationregulation of myofibroblast differentiation

Papers overview

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Highly Cited
2012
Highly Cited
2012
Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction.
The mechanical properties of the extracellular matrix have recently been shown to promote myofibroblast differentiation and lung… (More)
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Review
2011
Review
2011
Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases.
Progression of fibrosis involves interstitial hypercellularity, matrix accumulation, and atrophy of epithelial structures… (More)
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Highly Cited
2008
Highly Cited
2008
Osteopontin expression is required for myofibroblast differentiation.
Osteopontin (OPN) is a multifunctional cytokine that is strongly expressed in healing wounds and fibrotic lesions, both of which… (More)
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Highly Cited
2004
Highly Cited
2004
FIZZ1 stimulation of myofibroblast differentiation.
Bleomycin-induced pulmonary fibrosis is characterized by inflammation, emergence of myofibroblasts, and deposition of… (More)
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Highly Cited
2004
Highly Cited
2004
Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation.
Fibroblast proliferation, differentiation into myofibroblasts, and increased collagen synthesis are key events during both normal… (More)
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Highly Cited
2003
Highly Cited
2003
Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase.
Myofibroblast differentiation and activation by transforming growth factor-beta1 (TGF-beta1) is a critical event in the… (More)
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Highly Cited
2003
Highly Cited
2003
Mechanical force regulation of myofibroblast differentiation in cardiac fibroblasts.
The myocardium responds to chronic pressure or volume overload by activation and proliferation of cardiac fibroblasts and their… (More)
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Review
2002
Review
2002
The myofibroblast in pulmonary fibrosis.
The pathogenesis of pulmonary fibrosis remains incompletely understood. Studies of associated inflammation have led to the… (More)
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Highly Cited
2001
Highly Cited
2001
Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation.
We have examined the role of mechanical tension in myofibroblast differentiation using two in vivo rat models. In the first model… (More)
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Highly Cited
1996
Highly Cited
1996
Myofibroblasts differentiate from fibroblasts when plated at low density.
Myofibroblasts, defined by their expression of smooth muscle alpha-actin, appear at corneal and dermal incisions and promote… (More)
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